tert-butyl endo-3-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

• Chemical Name: tert-butyl endo-3-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate
• CAS No.: 1424336-90-2
• Molecular Formula: C₂₂H₂₉ClN₄O₄
• Molecular Weight: 448.95
• Mol file: 1424336-90-2.mol

Synonyms:tert-butyl endo-3-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate

Chemical Property of tert-butyl endo-3-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl endo-3-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 1 articles about tert-butyl endo-3-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl 3-endo-amino-8-azabicyclo[3.2.1]octane-8-carboxylate (207405-68-3,174486-93-2) + 2-chloro-6,7-dimethoxy-3H-quinazolin-4-one (27631-29-4) → tert-butyl endo-3-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate (1424336-90-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 20 ℃;

DOI:10.1016/j.bmc.2012.12.013

Reference yield:

4-methanesulfonylphenylamine (5470-49-5) + tert-butyl endo-3-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate (1424336-90-2) → C24H29N5O4S

Guidance literature:

4-methanesulfonylphenylamine; tert-butyl endo-3-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate; With hydrogenchloride; In water; butan-1-ol; at 130 ℃;

With sodium hydroxide; In water; butan-1-ol;

DOI:10.1016/j.bmc.2012.12.013

Reference yield:

tert-butyl endo-3-(2-chloro-6,7-dimethoxyquinazolin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate (1424336-90-2) → tert-butyl endo-3-(6,7-dimethoxy-2-(4-(methylsulfonyl)phenylamino)quinazolin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate (1424336-96-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / butan-1-ol; water / 130 °C

2: triethylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; triethylamine; In dichloromethane; water; butan-1-ol;

DOI:10.1016/j.bmc.2012.12.013

upstream raw materials:

tert-butyl 3-endo-amino-8-azabicyclo[3.2.1]octane-8-carboxylate

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

Downstream raw materials:

tert-butyl endo-3-(6,7-dimethoxy-2-(4-(methylsulfonyl)phenylamino)quinazolin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate