2-(3,5-di-t-butylphenyl)-2-methylpropylphosphonous dichloride

Base Information

• Chemical Name: 2-(3,5-di-t-butylphenyl)-2-methylpropylphosphonous dichloride
• CAS No.: 157643-36-2
• Molecular Formula: C₁₈H₂₉Cl₂P
• Molecular Weight: 347.308
• Mol file: 157643-36-2.mol

Synonyms:2-(3,5-di-t-butylphenyl)-2-methylpropylphosphonous dichloride

Chemical Property of 2-(3,5-di-t-butylphenyl)-2-methylpropylphosphonous dichloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,5-di-t-butylphenyl)-2-methylpropylphosphonous dichloride

There total 4 articles about 2-(3,5-di-t-butylphenyl)-2-methylpropylphosphonous dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,5-di-tert-butylphenyl)-2-methylpropanenitrile (68944-30-9) → 2-(3,5-di-t-butylphenyl)-2-methylpropylphosphonous dichloride (157643-36-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 66 percent / 9 M aq. H₂SO₄ / acetic acid / 52 h / Heating

2: 64 percent / BH₃*THF / tetrahydrofuran / 15 h / Ambient temperature

3: 85 percent / Ph₃P, diethylazidoformate, LiBr / tetrahydrofuran / 24 h / Ambient temperature

4: 1.) Mg, 2.) PCl₃ / 1.) Et₂O, RT, 3 h, ultrasonic irrad., 2.) Et₂O, from -78 deg C to RT

With borane-THF; sulfuric acid; magnesium; triphenylphosphine; lithium bromide; diethylazodicarboxylate; phosphorus trichloride; In tetrahydrofuran; acetic acid;

DOI:10.1246/bcsj.67.1980

Reference yield:

2-(3,5-di-t-butylphenyl)-2-methylpropanol (138535-18-9) → 2-(3,5-di-t-butylphenyl)-2-methylpropylphosphonous dichloride (157643-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / Ph₃P, diethylazidoformate, LiBr / tetrahydrofuran / 24 h / Ambient temperature

2: 1.) Mg, 2.) PCl₃ / 1.) Et₂O, RT, 3 h, ultrasonic irrad., 2.) Et₂O, from -78 deg C to RT

With magnesium; triphenylphosphine; lithium bromide; diethylazodicarboxylate; phosphorus trichloride; In tetrahydrofuran;

DOI:10.1246/bcsj.67.1980

Reference yield:

2-(3,5-di-t-butylphenyl)-2-methylpropanoic acid (157643-34-0) → 2-(3,5-di-t-butylphenyl)-2-methylpropylphosphonous dichloride (157643-36-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / BH₃*THF / tetrahydrofuran / 15 h / Ambient temperature

2: 85 percent / Ph₃P, diethylazidoformate, LiBr / tetrahydrofuran / 24 h / Ambient temperature

3: 1.) Mg, 2.) PCl₃ / 1.) Et₂O, RT, 3 h, ultrasonic irrad., 2.) Et₂O, from -78 deg C to RT

With borane-THF; magnesium; triphenylphosphine; lithium bromide; diethylazodicarboxylate; phosphorus trichloride; In tetrahydrofuran;

DOI:10.1246/bcsj.67.1980

upstream raw materials:

1-(1-bromo-2-methylpropan-2-yl)-3,5-di-tert-butylbenzene

2-(3,5-di-tert-butylphenyl)-2-methylpropanenitrile

2-(3,5-di-t-butylphenyl)-2-methylpropanol

2-(3,5-di-t-butylphenyl)-2-methylpropanoic acid

Downstream raw materials:

1,3,5-Tri-tert-butylbenzene

5,5'-(2,5-dimethylhexane-2,5-diyl)bis(1,3-di-tert-butylbenzene)

2-(3,5-di-t-butylphenyl)-2-methylpropylphosphine