(S)-octanedioic acid benzyloxy-amide (2-naphthalen-1-yl-1-phenethylcarbamoyl-ethyl)amide

Base Information

• Chemical Name: (S)-octanedioic acid benzyloxy-amide (2-naphthalen-1-yl-1-phenethylcarbamoyl-ethyl)amide
• CAS No.: 449729-01-5
• Molecular Formula: C₃₆H₄₁N₃O₄
• Molecular Weight: 579.739
• Mol file: 449729-01-5.mol

Synonyms:(S)-octanedioic acid benzyloxy-amide (2-naphthalen-1-yl-1-phenethylcarbamoyl-ethyl)amide

Chemical Property of (S)-octanedioic acid benzyloxy-amide (2-naphthalen-1-yl-1-phenethylcarbamoyl-ethyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-octanedioic acid benzyloxy-amide (2-naphthalen-1-yl-1-phenethylcarbamoyl-ethyl)amide

There total 4 articles about (S)-octanedioic acid benzyloxy-amide (2-naphthalen-1-yl-1-phenethylcarbamoyl-ethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

suberic acid monomethyl ester (3946-32-5) → (S)-octanedioic acid benzyloxy-amide (2-naphthalen-1-yl-1-phenethylcarbamoyl-ethyl)amide (449729-01-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / iPr₂NEt; BOP-Cl / CH₂Cl₂

2: 68 percent / aq. LiOH / tetrahydrofuran / 20 °C

3: 400 mg / NMM / tetrahydrofuran / 2.25 h

With 4-methyl-morpholine; lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm0208119

Reference yield:

O-benzylhydoxylamine hydrochloride (2687-43-6) → (S)-octanedioic acid benzyloxy-amide (2-naphthalen-1-yl-1-phenethylcarbamoyl-ethyl)amide (449729-01-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / iPr₂NEt; BOP-Cl / CH₂Cl₂

2: 68 percent / aq. LiOH / tetrahydrofuran / 20 °C

3: 400 mg / NMM / tetrahydrofuran / 2.25 h

With 4-methyl-morpholine; lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm0208119

Reference yield:

methyl N-benzyloxysuberoylamide (149648-49-7) → (S)-octanedioic acid benzyloxy-amide (2-naphthalen-1-yl-1-phenethylcarbamoyl-ethyl)amide (449729-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / aq. LiOH / tetrahydrofuran / 20 °C

2: 400 mg / NMM / tetrahydrofuran / 2.25 h

With 4-methyl-morpholine; lithium hydroxide; In tetrahydrofuran;

DOI:10.1021/jm0208119

upstream raw materials:

8-((benzyloxy)amino)-8-oxooctanoic acid

suberic acid monomethyl ester

O-benzylhydoxylamine hydrochloride

methyl N-benzyloxysuberoylamide