5-(4-methanesulfonyl-phenyl)-2-{1-[(1-trifluoromethyl-cyclopropyl)methyl]-piperidin-4-yl}-2,3-dihydro-furo[2,3-c]pyridine

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Chemical Name:5-(4-methanesulfonyl-phenyl)-2-{1-[(1-trifluoromethyl-cyclopropyl)methyl]-piperidin-4-yl}-2,3-dihydro-furo[2,3-c]pyridine
CAS No.:1443155-85-8
Molecular Formula:C₂₄H₂₇F₃N₂O₃S
Molecular Weight:480.551
Hs Code.:

Synonyms:5-(4-methanesulfonyl-phenyl)-2-{1-[(1-trifluoromethyl-cyclopropyl)methyl]-piperidin-4-yl}-2,3-dihydro-furo[2,3-c]pyridine

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Chemical Property of 5-(4-methanesulfonyl-phenyl)-2-{1-[(1-trifluoromethyl-cyclopropyl)methyl]-piperidin-4-yl}-2,3-dihydro-furo[2,3-c]pyridine

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Technology Process of 5-(4-methanesulfonyl-phenyl)-2-{1-[(1-trifluoromethyl-cyclopropyl)methyl]-piperidin-4-yl}-2,3-dihydro-furo[2,3-c]pyridine

There total 7 articles about 5-(4-methanesulfonyl-phenyl)-2-{1-[(1-trifluoromethyl-cyclopropyl)methyl]-piperidin-4-yl}-2,3-dihydro-furo[2,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262400-04-3
methanesulfonic acid (1-(trifluoromethyl)cyclopropyl)methyl ester

: 1382136-68-6
5-(4-methanesulfonyl-phenyl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine

: 1443155-85-8
5-(4-methanesulfonyl-phenyl)-2-{1-[(1-trifluoromethyl-cyclopropyl)methyl]-piperidin-4-yl}-2,3-dihydro-furo[2,3-c]pyridine

Guidance literature:: With potassium carbonate; potassium iodide; In 1-methyl-pyrrolidin-2-one; at 20 - 100 ℃;

Reference yield:

: 778611-64-6
5-bromo-2-chloro-4-methylpyridine

: 1443155-85-8
5-(4-methanesulfonyl-phenyl)-2-{1-[(1-trifluoromethyl-cyclopropyl)methyl]-piperidin-4-yl}-2,3-dihydro-furo[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / water; tetrahydrofuran / 2 h / -40 - -35 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: sodium tetrahydroborate / water; tetrahydrofuran / 0.5 h / 20 °C

3.1: caesium carbonate; palladium diacetate; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl / toluene / 5 h / 110 °C / Inert atmosphere

4.1: sodium carbonate / 1,4-dioxane; water / 0.17 h / Inert atmosphere

4.2: 150 °C / Microwave irradiation

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 20 - 100 °C

With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; sodium tetrahydroborate; palladium diacetate; sodium carbonate; potassium carbonate; caesium carbonate; trifluoroacetic acid; potassium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; toluene;

Reference yield:

: 1382136-92-6
4-[2-(5-bromo-2-chloro-pyridin-4-yl)-1-hydroxy-ethyl]-piperidine-1-carboxylic acid tert-butyl ester

: 1443155-85-8
5-(4-methanesulfonyl-phenyl)-2-{1-[(1-trifluoromethyl-cyclopropyl)methyl]-piperidin-4-yl}-2,3-dihydro-furo[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate; palladium diacetate; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl / toluene / 5 h / 110 °C / Inert atmosphere

2.1: sodium carbonate / 1,4-dioxane; water / 0.17 h / Inert atmosphere

2.2: 150 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 20 - 100 °C

With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium diacetate; sodium carbonate; potassium carbonate; caesium carbonate; trifluoroacetic acid; potassium iodide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; toluene;