1-(2'-O-methyl-3',5'-di-O-benzyl-4'-C-trifluoroacetylaminomethyl-β-D-ribofuranosyl)uracil

Base Information

Chemical Name:1-(2'-O-methyl-3',5'-di-O-benzyl-4'-C-trifluoroacetylaminomethyl-β-D-ribofuranosyl)uracil
CAS No.:1361928-11-1
Molecular Formula:C₂₇H₂₈F₃N₃O₇
Molecular Weight:563.53
Hs Code.:

Synonyms:1-(2'-O-methyl-3',5'-di-O-benzyl-4'-C-trifluoroacetylaminomethyl-β-D-ribofuranosyl)uracil

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Chemical Property of 1-(2'-O-methyl-3',5'-di-O-benzyl-4'-C-trifluoroacetylaminomethyl-β-D-ribofuranosyl)uracil

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Technology Process of 1-(2'-O-methyl-3',5'-di-O-benzyl-4'-C-trifluoroacetylaminomethyl-β-D-ribofuranosyl)uracil

There total 7 articles about 1-(2'-O-methyl-3',5'-di-O-benzyl-4'-C-trifluoroacetylaminomethyl-β-D-ribofuranosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 383-63-1
ethyl trifluoroacetate,

: C₂₅H₂₉N₃O₆

: 1361928-11-1
1-(2'-O-methyl-3',5'-di-O-benzyl-4'-C-trifluoroacetylaminomethyl-β-D-ribofuranosyl)uracil

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jo202666m

Reference yield:

: 1361928-07-5
C₃₂H₃₃N₅O₇

: 1361928-11-1
1-(2'-O-methyl-3',5'-di-O-benzyl-4'-C-trifluoroacetylaminomethyl-β-D-ribofuranosyl)uracil

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: ammonium cerium (IV) nitrate / water; acetonitrile / 55 h / 20 °C

3.1: water; triphenylphosphine / tetrahydrofuran / 4 h / 45 °C

4.1: triethylamine / tetrahydrofuran / 0 - 20 °C

With ammonium cerium (IV) nitrate; water; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jo202666m

Reference yield:

: 1361928-10-0
1-(2'-O-methyl-3',5'-di-O-benzyl-4'-C-azidomethyl-β-D-ribofuranosyl)uracil

: 1361928-11-1
1-(2'-O-methyl-3',5'-di-O-benzyl-4'-C-trifluoroacetylaminomethyl-β-D-ribofuranosyl)uracil

Guidance literature:: Multi-step reaction with 2 steps

1: water; triphenylphosphine / tetrahydrofuran / 4 h / 45 °C

2: triethylamine / tetrahydrofuran / 0 - 20 °C

With water; triethylamine; triphenylphosphine; In tetrahydrofuran;
DOI:10.1021/jo202666m