4-Bromo-2-ethylthiophene

Base Information

• Chemical Name: 4-Bromo-2-ethylthiophene
• CAS No.: 83663-40-5
• Molecular Formula: C₆H₇BrS
• Molecular Weight: 191.092
• Mol file: 83663-40-5.mol

Synonyms:4-Bromo-2-ethylthiophene

Chemical Property of 4-Bromo-2-ethylthiophene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

KK002213:4-bromo-2-ethylthiophene 98 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Bromo-2-ethylthiophene

There total 5 articles about 4-Bromo-2-ethylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-bromo-5-ethylthiophene (62323-44-8) → 4-Bromo-2-ethylthiophene (83663-40-5)

Guidance literature:

2-bromo-5-ethylthiophene; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 2h; Inert atmosphere;

With methanol; In tetrahydrofuran; at -70 - 20 ℃; Inert atmosphere;

DOI:10.1039/c6md00128a

Reference yield: 65.0%

2-acetyl-4-bromothiopene (7209-11-2) → 4-Bromo-2-ethylthiophene (83663-40-5)

Guidance literature:

With potassium salt of hydrazide; hydrazine hydrate; In ethylene glycol; 1) 160 deg C, 0.5 h, 2) 160 deg C, 1 h.;

Reference yield:

2-ethylthiophene (872-55-9) → 4-Bromo-2-ethylthiophene (83663-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid; N-Bromosuccinimide / chloroform / 3 h / 0 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere

2.2: 2 h / -70 °C

With N-Bromosuccinimide; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; chloroform;

upstream raw materials:

2-acetyl-4-bromothiopene

2-Acetylthiophene

2-bromo-5-ethylthiophene

2-ethylthiophene

Downstream raw materials:

2-ethyl-4-(trimethylsilylethynyl)thiophene

Refernces

• 1、 -. "HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF". Paragraph 00286. . Retrieved 2013/08/28.
• 2、 Alvares-Insua, A. S.,Conde, S.,Corral, C.. "Bromothiophene Reactions. II. A Novel Rearrangement in the Zinc and Acetic Acid Reduction". . p. 713 - 716. Retrieved 2007/10/02.