2-[[[2-(2,4-difluorophenyl)-2-oxiranyl]difluoromethyl]thio]ethyl acetate

Base Information

Chemical Name:2-[[[2-(2,4-difluorophenyl)-2-oxiranyl]difluoromethyl]thio]ethyl acetate
CAS No.:201034-39-1
Molecular Formula:C₁₃H₁₂F₄O₃S
Molecular Weight:324.296
Hs Code.:

Synonyms:2-[[[2-(2,4-difluorophenyl)-2-oxiranyl]difluoromethyl]thio]ethyl acetate

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Chemical Property of 2-[[[2-(2,4-difluorophenyl)-2-oxiranyl]difluoromethyl]thio]ethyl acetate

Chemical Property:

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Technology Process of 2-[[[2-(2,4-difluorophenyl)-2-oxiranyl]difluoromethyl]thio]ethyl acetate

There total 4 articles about 2-[[[2-(2,4-difluorophenyl)-2-oxiranyl]difluoromethyl]thio]ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1774-47-6
trimethylsulfoxonium iodide

: 201034-35-7
2-(2-acetoxyethylthio)-2,2,2',4'-tetrafluoroacetophenone

: 201034-39-1
2-[[[2-(2,4-difluorophenyl)-2-oxiranyl]difluoromethyl]thio]ethyl acetate

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 1h;

2-(2-acetoxyethylthio)-2,2,2',4'-tetrafluoroacetophenone; In tetrahydrofuran; dimethyl sulfoxide; at 0 ℃; for 1h;
DOI:10.1248/cpb.49.173

Reference yield:

: 102429-07-2
2-bromo-2',4'-difluoroacetophenone

: 201034-39-1
2-[[[2-(2,4-difluorophenyl)-2-oxiranyl]difluoromethyl]thio]ethyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 72 percent / dimethylsulfoxide / 15 h / 20 °C

2.1: 97 percent / pyridine / 3 h / 50 °C

3.1: 45 percent / N-fluoro-2,4,6-trimethylpyridinium triflate; zinc bromide / 1,1,2-trichloro-ethane / 80 - 105 °C

4.1: NaH / dimethylsulfoxide; tetrahydrofuran / 1 h / 20 °C

4.2: 90 percent / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C

With pyridine; sodium hydride; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; zinc dibromide; In tetrahydrofuran; 1,1,2-trichloroethane; dimethyl sulfoxide;
DOI:10.1248/cpb.49.173

Reference yield:

: 201034-30-2
2',4'-difluoro-2-[(2-hydroxyethyl)thio]acetophenone

: 201034-39-1
2-[[[2-(2,4-difluorophenyl)-2-oxiranyl]difluoromethyl]thio]ethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / pyridine / 3 h / 50 °C

2.1: 45 percent / N-fluoro-2,4,6-trimethylpyridinium triflate; zinc bromide / 1,1,2-trichloro-ethane / 80 - 105 °C

3.1: NaH / dimethylsulfoxide; tetrahydrofuran / 1 h / 20 °C

3.2: 90 percent / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C

With pyridine; sodium hydride; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; zinc dibromide; In tetrahydrofuran; 1,1,2-trichloroethane; dimethyl sulfoxide;
DOI:10.1248/cpb.49.173