201034-30-2

Usage

General Description

2',4'-difluoro-2-[(2-hydroxyethyl)thio]acetophenone is a chemical compound that is a derivative of acetophenone with two fluorine atoms at the 2' and 4' positions, and a thiol group attached to the 2 position. It is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds due to its ability to serve as a versatile building block for a variety of chemical reactions. 2',4'-difluoro-2-[(2-hydroxyethyl)thio]acetophenone has potential applications in the development of new drugs, as well as in the production of fine chemicals and other industrially important products. Additionally, its unique structure and reactivity make it a valuable tool for chemical research and development.

Upstream product

• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 60-24-2 2-hydroxyethanethiol 
• 102429-07-2 2-bromo-2',4'-difluoroacetophenone 

Downstream Products

• 201034-46-0 2-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propylthio]ethyl acetate 
• 201034-54-0 2-(2,4-difluorophenyl)-1,1-difluoro-1-[(2-hydroxyethyl)thio]-3-(1H-1,2,4-triazol-1-yl)-2-propanol 
• 201034-39-1 2-[[[2-(2,4-difluorophenyl)-2-oxiranyl]difluoromethyl]thio]ethyl acetate 
• 201034-35-7 2-(2-acetoxyethylthio)-2,2,2',4'-tetrafluoroacetophenone 
• 201034-31-3 α-[(β'-acetoxyethyl)thio]-2',4'-difluoroacetophenone 

Relevant academic research and scientific papers

New antifungal 1,2,4-triazoles with difluoro(substituted sulfonyl)methyl moiety

New 1,2,4-triazoles (2) having a difluoro(substituted sulfonyl)methyl moiety were designed and synthesized via α,α-difluoro-α-(substituted thio)acetophenones (3). Compounds (2) showed potent antifungal activities against C. albicans, C. krusei, A. flavus

α, α-gem-difluorination of α-(alkylthio)acetophenone derivatives with N-Fluoropyridinium salts

The α, α-gem-difluorination of 2',4'-difluoro- α(methylthio)acetophenone (1a) with N-fluoropyridinium salts gave 2',4',α-tetrafluoro-α-(methylthio)acetophenone (3a). This reaction was accelerated by the addition of zinc chloride, zinc bromide or anhydrous iron(III) chloride, and higher yields than the reaction without additives were obtained. The gem- difluorination reaction using FP-T300 in the presence of zinc bromide was applicable to other α-(alkylthio)acetophenone derivatives (1).