(2S)-(tert-butyldimethylsilanyloxymethyl)-1-[(1R)-1-(tert-butyldiphenylsilanyloxymethyl)-4-methoxymethoxy-2-butynyl]pyrrolidine

Base Information

Chemical Name:(2S)-(tert-butyldimethylsilanyloxymethyl)-1-[(1R)-1-(tert-butyldiphenylsilanyloxymethyl)-4-methoxymethoxy-2-butynyl]pyrrolidine
CAS No.:862107-71-9
Molecular Formula:C₃₄H₅₃NO₄Si₂
Molecular Weight:595.97
Hs Code.:

Synonyms:(2S)-(tert-butyldimethylsilanyloxymethyl)-1-[(1R)-1-(tert-butyldiphenylsilanyloxymethyl)-4-methoxymethoxy-2-butynyl]pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-(tert-butyldimethylsilanyloxymethyl)-1-[(1R)-1-(tert-butyldiphenylsilanyloxymethyl)-4-methoxymethoxy-2-butynyl]pyrrolidine

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Technology Process of (2S)-(tert-butyldimethylsilanyloxymethyl)-1-[(1R)-1-(tert-butyldiphenylsilanyloxymethyl)-4-methoxymethoxy-2-butynyl]pyrrolidine

There total 1 articles about (2S)-(tert-butyldimethylsilanyloxymethyl)-1-[(1R)-1-(tert-butyldiphenylsilanyloxymethyl)-4-methoxymethoxy-2-butynyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 17869-81-7
methoxy(prop-2-yn-1-yloxy)methane

: 115869-43-7
(tert-butyldiphenylsilanyloxy)acetaldehyde

: 134756-75-5
(2S)-2-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)pyrrolidine

: 862107-71-9
(2S)-(tert-butyldimethylsilanyloxymethyl)-1-[(1R)-1-(tert-butyldiphenylsilanyloxymethyl)-4-methoxymethoxy-2-butynyl]pyrrolidine

Guidance literature:: With 4 A molecular sieve; copper(I) bromide; In toluene; at 20 ℃; for 20h;
DOI:10.1021/ol050578j

Reference yield: 100.0%

: 862107-71-9
(2S)-(tert-butyldimethylsilanyloxymethyl)-1-[(1R)-1-(tert-butyldiphenylsilanyloxymethyl)-4-methoxymethoxy-2-butynyl]pyrrolidine

: 862107-72-0
(2S)-(tert-butyldimethylsilanyloxymethyl)-1-[(1R)-1-(tert-butyldiphenylsilanyloxymethyl)-4-methoxymethoxy-2-butenyl]pyrrolidine

Guidance literature:: With hydrogen; Lindlar's catalyst; In ethyl acetate; at 20 ℃; for 1h;
DOI:10.1021/ol050578j

Reference yield:

: 862107-71-9
(2S)-(tert-butyldimethylsilanyloxymethyl)-1-[(1R)-1-(tert-butyldiphenylsilanyloxymethyl)-4-methoxymethoxy-2-butynyl]pyrrolidine

: 862107-67-3
(3S,4R)-3-Benzyloxy-5-[2-(tert-butyl-diphenyl-silanyloxy)-1-iodo-ethyl]-4-methoxymethoxymethyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Lindlar catalyst / ethyl acetate / 1 h / 20 °C

2: 64 percent / Zn(OSO₂CF₃)2; i-Pr₂NEt / CH₂Cl₂ / 0 °C

3: I₂ / tetrahydrofuran; H₂O / 4 h / 0 °C

With hydrogen; iodine; zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; Lindlar's catalyst; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1021/ol050578j