4-(aminomethyl)-4-[(4-fluorophenyl)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: 4-(aminomethyl)-4-[(4-fluorophenyl)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
• CAS No.: 894769-76-7
• Molecular Formula: C₁₈H₂₇FN₂O₂
• Molecular Weight: 322.423

Synonyms:4-(aminomethyl)-4-[(4-fluorophenyl)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property of 4-(aminomethyl)-4-[(4-fluorophenyl)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property:

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Technology Process of 4-(aminomethyl)-4-[(4-fluorophenyl)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

There total 1 articles about 4-(aminomethyl)-4-[(4-fluorophenyl)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-cyano-4-(4-fluorobenzyl)piperidine-1-carboxylate (894769-77-8) → 4-(aminomethyl)-4-[(4-fluorophenyl)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester (894769-76-7)

Guidance literature:

With ammonia; hydrogen; nickel; In methanol; at 0 - 20 ℃; for 2h;

Reference yield:

4-(aminomethyl)-4-[(4-fluorophenyl)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester (894769-76-7) + methyl iodide (74-88-4) → 4-[(dimethylamino)methyl]-4-[(4-fluorophenyl)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester (894769-84-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

4-(aminomethyl)-4-[(4-fluorophenyl)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester (894769-76-7) + trifluoroacetic anhydride (407-25-0) → 4-[(4-fluorophenyl)methyl]-4-[[(trifluoroacetyl)amino]methyl]-1-piperidinecarboxylic acid ,1,1-dimethylethyl ester (894769-78-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

tert-butyl 4-cyano-4-(4-fluorobenzyl)piperidine-1-carboxylate

Downstream raw materials:

4-[(dimethylamino)methyl]-4-[(4-fluorophenyl)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

4-[(4-fluorophenyl)methyl]-4-[[(trifluoroacetyl)amino]methyl]-1-piperidinecarboxylic acid ,1,1-dimethylethyl ester

4-[(4-fluorophenyl)methyl]-4-(1-piperidinylmethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

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