1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime

Base Information

• Chemical Name: 1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime
• CAS No.: 145084-54-4
• Molecular Formula: C₂₄H₁₉N₃O₄
• Molecular Weight: 413.433
• Mol file: 145084-54-4.mol

Synonyms:1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime

Chemical Property of 1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime

There total 1 articles about 1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one (145084-53-3) → 1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime (145084-54-4)

Guidance literature:

With potassium tert-butylate; isopentyl nitrite; Yield given. Multistep reaction; 1.) toluene, -20 deg C, 45 min, 2.) toluene, from -20 to -15 deg C, 2 h;

DOI:10.1248/cpb.43.2159

Reference yield: 73.0%

1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime (145084-54-4) → 3-Amino-1-[2-(2-methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one (145084-52-2)

Guidance literature:

With hydrogen; Ru-carbon; In methanol; at 60 ℃; under 6080 Torr;

DOI:10.1248/cpb.43.2159

Reference yield:

1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime (145084-54-4) → 1-{1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl}-3-m-tolyl-urea

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / H₂ / 5percent Ru/C / methanol / 60 °C / 6080 Torr

2: 69 percent / tetrahydrofuran / 4 h / Ambient temperature

With hydrogen; Ru-carbon; In tetrahydrofuran; methanol;

DOI:10.1248/cpb.43.2159

upstream raw materials:

1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Downstream raw materials:

3-Amino-1-[2-(2-methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one