3-Amino-1-[2-(2-methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Base Information

• Chemical Name: 3-Amino-1-[2-(2-methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
• CAS No.: 145084-52-2
• Molecular Formula: C₂₄H₂₁N₃O₃
• Molecular Weight: 399.449
• Mol file: 145084-52-2.mol

Synonyms:3-Amino-1-[2-(2-methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Chemical Property of 3-Amino-1-[2-(2-methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Amino-1-[2-(2-methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

There total 4 articles about 3-Amino-1-[2-(2-methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime (145084-54-4) → 3-Amino-1-[2-(2-methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one (145084-52-2)

Guidance literature:

With hydrogen; Ru-carbon; In methanol; at 60 ℃; under 6080 Torr;

DOI:10.1248/cpb.43.2159

Reference yield:

bromomethyl 2-methoxyphenyl ketone (31949-21-0) → 3-Amino-1-[2-(2-methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one (145084-52-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / 50percent aq. NaOH, Aliquat 336 / toluene / 6 h / Ambient temperature

2: 1.) t-BuOK, 2.) i-AmONO / 1.) toluene, -20 deg C, 45 min, 2.) toluene, from -20 to -15 deg C, 2 h

3: 73 percent / H₂ / 5percent Ru/C / methanol / 60 °C / 6080 Torr

With sodium hydroxide; potassium tert-butylate; hydrogen; Aliquat 336; isopentyl nitrite; Ru-carbon; In methanol; toluene;

DOI:10.1248/cpb.43.2159

Reference yield:

1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one (145084-53-3) → 3-Amino-1-[2-(2-methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one (145084-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) t-BuOK, 2.) i-AmONO / 1.) toluene, -20 deg C, 45 min, 2.) toluene, from -20 to -15 deg C, 2 h

2: 73 percent / H₂ / 5percent Ru/C / methanol / 60 °C / 6080 Torr

With potassium tert-butylate; hydrogen; isopentyl nitrite; Ru-carbon; In methanol;

DOI:10.1248/cpb.43.2159

upstream raw materials:

1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime

bromomethyl 2-methoxyphenyl ketone

1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one