(1S,2R)-2-benzyloxymethylcyclopropyl phenyl sulfone

Base Information

• Chemical Name: (1S,2R)-2-benzyloxymethylcyclopropyl phenyl sulfone
• CAS No.: 1233934-54-7
• Molecular Formula: C₁₇H₁₈O₃S
• Molecular Weight: 302.394
• Mol file: 1233934-54-7.mol

Synonyms:(1S,2R)-2-benzyloxymethylcyclopropyl phenyl sulfone

Chemical Property of (1S,2R)-2-benzyloxymethylcyclopropyl phenyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (1S,2R)-2-benzyloxymethylcyclopropyl phenyl sulfone

There total 1 articles about (1S,2R)-2-benzyloxymethylcyclopropyl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

diethyl phenylsulfonylmethylphosphonate (56069-39-7) + (S)-benzyl glycidyl ether (2930-05-4,14618-80-5,89616-40-0,16495-13-9) → (1S,2R)-2-benzyloxymethylcyclopropyl phenyl sulfone (1233934-54-7)

Guidance literature:

diethyl phenylsulfonylmethylphosphonate; With sodium hydride; In 1,2-dimethoxyethane; at 25 ℃;

(S)-benzyl glycidyl ether; In 1,2-dimethoxyethane; at 140 ℃; diastereoselective reaction;

DOI:10.1021/jo100844g

Reference yield: 65.0%

iodo(trimethylsilyl)methane (4206-67-1) + (1S,2R)-2-benzyloxymethylcyclopropyl phenyl sulfone (1233934-54-7) → 1-phenylsulfonyl-1-trimethylsilylmethyl-2-benzyloxymethylcyclopropane (139242-80-1)

Guidance literature:

(1S,2R)-2-benzyloxymethylcyclopropyl phenyl sulfone; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.533333h;

iodo(trimethylsilyl)methane; In tetrahydrofuran; at -78 - 20 ℃; for 3.03333h;

DOI:10.1021/jo100844g

upstream raw materials:

diethyl phenylsulfonylmethylphosphonate

(S)-benzyl glycidyl ether

Downstream raw materials:

1-phenylsulfonyl-1-trimethylsilylmethyl-2-benzyloxymethylcyclopropane