1-(3-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)-3-(furan-2-ylmethyl)urea

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Chemical Name:1-(3-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)-3-(furan-2-ylmethyl)urea
CAS No.:1430724-53-0
Molecular Formula:C₂₅H₂₀N₈O₂
Molecular Weight:464.486
Hs Code.:

Synonyms:1-(3-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)-3-(furan-2-ylmethyl)urea

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Chemical Property of 1-(3-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)-3-(furan-2-ylmethyl)urea

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Technology Process of 1-(3-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)-3-(furan-2-ylmethyl)urea

There total 11 articles about 1-(3-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)-3-(furan-2-ylmethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1430728-11-2
3-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)aniline

: 71189-15-6
2-(isocyanatomethyl)furan

: 1430724-53-0
1-(3-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)-3-(furan-2-ylmethyl)urea

Guidance literature:: With triethylamine; In dichloromethane; for 1h;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1430724-53-0
1-(3-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)-3-(furan-2-ylmethyl)urea

Guidance literature:: Multi-step reaction with 10 steps

1: acetic acid; iron / acetic acid / 0.5 h / 90 °C

2: 0.5 h / 0 - 20 °C

3: caesium carbonate; copper(I) oxide / N,N-dimethyl-formamide / 16 h / 120 °C

4: water; calcium chloride; iron / ethanol / 4 h / 100 °C

5: potassium fluoride / N,N-dimethyl-formamide / 4 h / 150 °C

6: water; calcium chloride; iron / ethanol / 4 h / 100 °C

7: 0.5 h / 100 °C

8: caesium carbonate; copper(I) oxide / N,N-dimethyl-formamide / 12 h / 110 °C

9: sodium hydroxide; water / ethanol / 3 h / 90 °C

10: triethylamine / dichloromethane / 1 h

With copper(I) oxide; potassium fluoride; water; iron; caesium carbonate; acetic acid; triethylamine; calcium chloride; sodium hydroxide; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 99-65-0
meta-dinitrobenzene

: 1430724-53-0
1-(3-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)-3-(furan-2-ylmethyl)urea

Guidance literature:: Multi-step reaction with 11 steps

1: sulfuric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 12.5 h / 0 - 20 °C

2: acetic acid; iron / acetic acid / 0.5 h / 90 °C

3: 0.5 h / 0 - 20 °C

4: caesium carbonate; copper(I) oxide / N,N-dimethyl-formamide / 16 h / 120 °C

5: water; calcium chloride; iron / ethanol / 4 h / 100 °C

6: potassium fluoride / N,N-dimethyl-formamide / 4 h / 150 °C

7: water; calcium chloride; iron / ethanol / 4 h / 100 °C

8: 0.5 h / 100 °C

9: caesium carbonate; copper(I) oxide / N,N-dimethyl-formamide / 12 h / 110 °C

10: sodium hydroxide; water / ethanol / 3 h / 90 °C

11: triethylamine / dichloromethane / 1 h

With copper(I) oxide; potassium fluoride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; water; iron; caesium carbonate; acetic acid; triethylamine; calcium chloride; sodium hydroxide; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;