1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE

Base Information

• Chemical Name: 1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE
• CAS No.: 159877-36-8
• Molecular Formula: C12H22N2O2
• Molecular Weight: 226.319
• Hs Code.: 2933990090
• Mol file: 159877-36-8.mol

Synonyms:tert-Butyloctahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate;Octahydropyrrolo[3,4-b]pyridine-1-carboxylicacid tert-butyl ester;

Chemical Property of 1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.489
• Boiling Point: 313.81 °C at 760 mmHg
• PKA: 10.66±0.20(Predicted)
• Flash Point: 143.587 °C
• PSA: 41.57000
• Density: 1.053 g/cm³
• LogP: 1.87200
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-octahydropyrrolo[3,4-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE

There total 8 articles about 1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4aR,7aR)-tert-butyl 6-benzyloctahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate (868136-22-5) → tert-butyl (4aR,7aR)-octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate (159877-36-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; water;

Reference yield:

tert-butyl 6-benzyloctahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate (159877-35-7) → octahydro-pyrrolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester (159877-36-8)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; at 20 ℃; for 2h;

Reference yield:

cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]-nonane → octahydro-pyrrolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester (159877-36-8)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / Inert atmosphere; Reflux

2: sodium carbonate / tetrahydrofuran; water / 0 - 20 °C

3: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 2 h / 20 °C

With lithium aluminium tetrahydride; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium carbonate; In tetrahydrofuran; methanol; water;

upstream raw materials:

(4aR,7aR)-tert-butyl 6-benzyloctahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate

tert-butyl 6-benzyloctahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate

6-benzyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione

(R,R)-8-benzyl-2,8-diazabicyclo[4.3.0]-nonane

Downstream raw materials:

8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-ylcarbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[3,4-b] pyridine-1-carboxylate

N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl)propoxy)-7-methoxyquinazolin-4-amine