159877-35-7

Usage

Uses

Used in Organic Synthesis:
1-Boc-6-benzyloctahydropyrrolo[3,4-b]pyridine is used as a building block for the synthesis of complex organic molecules. Its unique structure allows for the creation of a wide range of compounds with potential applications in various fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-Boc-6-benzyloctahydropyrrolo[3,4-b]pyridine is utilized as a precursor for the synthesis of biologically active molecules. Its presence in the molecular structure can contribute to the development of new drugs with specific therapeutic properties.
Used as a Protective Group:
1-Boc-6-benzyloctahydropyrrolo[3,4-b]pyridine serves as a protective group for amines and amides during chemical reactions. This function is crucial in organic synthesis to prevent unwanted side reactions and ensure the desired product is obtained.
Used in the Synthesis of Heterocyclic Compounds:
1-Boc-6-benzyloctahydropyrrolo[3,4-b]pyridine is a versatile intermediate in the synthesis of heterocyclic compounds, which are important in medicinal chemistry. The ability to incorporate 1-Boc-6-benzyloctahydropyrrolo[3,4-b]pyridine into heterocyclic structures expands the range of potential drug candidates and other chemical entities.
Used in Drug Development:
1-Boc-6-benzyloctahydropyrrolo[3,4-b]pyridine is instrumental in the development of new drugs and pharmaceuticals. Its incorporation into drug molecules can enhance their efficacy, selectivity, and pharmacokinetic properties, leading to improved therapeutic outcomes.

InChI:InChI=1/C19H28N2O2/c1-19(2,3)23-18(22)21-11-7-10-16-13-20(14-17(16)21)12-15-8-5-4-6-9-15/h4-6,8-9,16-17H,7,10-14H2,1-3H3

Upstream product

• 100-46-9 benzylamine 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 18184-75-3 6-benzyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 
• 128740-14-7 (R,R)-8-benzyl-2,8-diazabicyclo[4.3.0]-nonane 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 159877-36-8 octahydro-pyrrolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester 
• 1438073-26-7 N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438082-56-4 tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[3,4-b] pyridine-1-carboxylate 

Relevant academic research and scientific papers

Discovery of novel substituted octahydropyrrolo[3,4-c]pyrroles as dual orexin receptor antagonists for insomnia treatment

A series of octahydropyrrolo[3,4-c]pyrroles were synthesized and evaluated by orexin 1 and 2 receptor (OX1 & 2R) antagonists assays. Compound 14l with potent OXR antagonist activity and suitable pharmacokinetic behavior was chosen to be investigated in an EEG study, which demonstrated effects of sleep promotion comparable to Suvorexant. Furthermore, the di-fluro substituted analogs exhibited reduced hERG inhibition while maintaining moderate potency.

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter-and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

Bicyclic amine derivatives

A compound represented by formula (I) or a salt thereof: STR1 wherein X1 and X2 each represent a halogen atom; R1 represents a hydrogen atom or a substituent; R2 represents a substituted or unsubstituted bicyclic heterocyclic substituent of the following formula; STR2 wherein R3, R4, Y, Z, m, n, p, q and r are as defined herein; A represents a nitrogen atom or a substituted carbon atom; and R represents a hydrogen atom or a substituent. The compound exhibits potent antimicrobial activity and also high safety due to reduced lipophilicity.