4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzamide

Base Information

Chemical Name:4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzamide
CAS No.:1374970-49-6
Molecular Formula:C₂₂H₂₄FN₅O₂
Molecular Weight:409.463
Hs Code.:

Synonyms:4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzamide

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Chemical Property of 4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzamide

Chemical Property:

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Technology Process of 4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzamide

There total 5 articles about 4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374970-51-0
4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzonitrile

: 1374970-49-6
4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzamide

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In ethanol; water; at 20 ℃; for 1h;

Reference yield:

: 365996-30-1
tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate

: 1374970-49-6
4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 100 °C

2: sodium phenoxide trihydrate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 170 °C / Inert atmosphere; Microwave irradiation

3: trifluoroacetic acid / 0.33 h

4: sodium hydroxide; dihydrogen peroxide / ethanol; water / 1 h / 20 °C

With sodium phenoxide trihydrate; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 64695-82-5
2-bromo-4,5-difluorobenzonitrile

: 1374970-49-6
4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 100 °C

2: sodium phenoxide trihydrate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 170 °C / Inert atmosphere; Microwave irradiation

3: trifluoroacetic acid / 0.33 h

4: sodium hydroxide; dihydrogen peroxide / ethanol; water / 1 h / 20 °C

With sodium phenoxide trihydrate; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide;