3-[(3,4-dihydroxy-4-methylpentyl)oxy]-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

Base Information

Chemical Name:3-[(3,4-dihydroxy-4-methylpentyl)oxy]-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide
CAS No.:1373870-85-9
Molecular Formula:C₁₈H₂₁FIN₃O₄
Molecular Weight:489.285
Hs Code.:

Synonyms:3-[(3,4-dihydroxy-4-methylpentyl)oxy]-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

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Chemical Property of 3-[(3,4-dihydroxy-4-methylpentyl)oxy]-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

Chemical Property:

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Technology Process of 3-[(3,4-dihydroxy-4-methylpentyl)oxy]-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

There total 4 articles about 3-[(3,4-dihydroxy-4-methylpentyl)oxy]-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1373870-84-8
3-[(2-fluoro-4-iodophenyl)amino]-5-[(4-methylpent-3-en-1-yl)oxy]isonicotinamide

: 1373870-85-9
3-[(3,4-dihydroxy-4-methylpentyl)oxy]-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

Guidance literature:: With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; In acetone; tert-butyl alcohol; at 20 ℃; for 18h;

Reference yield:

: 1373870-91-7
3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

: 1373870-85-9
3-[(3,4-dihydroxy-4-methylpentyl)oxy]-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 120 h / 70 °C

2: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol; acetone / 18 h / 20 °C

With osmium(VIII) oxide; water; caesium carbonate; 4-methylmorpholine N-oxide; In N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

Reference yield:

: 903522-29-2
3,5-difluoro-4-pyridinecarboxylic acid

: 1373870-85-9
3-[(3,4-dihydroxy-4-methylpentyl)oxy]-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / 3 - 20 °C / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1.5 h / 60 °C / Inert atmosphere

2.2: 18 h / 3 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 120 h / 70 °C

4.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol; acetone / 18 h / 20 °C

With osmium(VIII) oxide; water; caesium carbonate; 4-methylmorpholine N-oxide; 1,1'-carbonyldiimidazole; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;