(S)-1-(4-chlorophenyl)-2-phenoxyethanol

Base Information

Chemical Name:(S)-1-(4-chlorophenyl)-2-phenoxyethanol
CAS No.:1304788-11-1
Molecular Formula:C₁₄H₁₃ClO₂
Molecular Weight:248.709
Hs Code.:

Synonyms:(S)-1-(4-chlorophenyl)-2-phenoxyethanol

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Chemical Property of (S)-1-(4-chlorophenyl)-2-phenoxyethanol

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Technology Process of (S)-1-(4-chlorophenyl)-2-phenoxyethanol

There total 4 articles about (S)-1-(4-chlorophenyl)-2-phenoxyethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 41806-25-1
4-chloro-α-phenoxyacetophenone

: 1304788-11-1
(S)-1-(4-chlorophenyl)-2-phenoxyethanol

Guidance literature:: With formic acid; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; triethylamine; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; In tetrahydrofuran; at 20 ℃; for 24h; optical yield given as %ee; Inert atmosphere;
DOI:10.2174/157017811799304197

Reference yield: 89.0%

: 2788-86-5,21019-51-2,53649-47-1,97466-49-4
(2S)-2-(4-chlorophenyl)oxirane

: 108-95-2,27073-41-2
phenol

: 1304788-11-1
(S)-1-(4-chlorophenyl)-2-phenoxyethanol

Guidance literature:: phenol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

(2S)-2-(4-chlorophenyl)oxirane; In N,N-dimethyl-formamide; at 60 ℃; for 24h; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/jo102294j

Reference yield:

: 179065-35-1
(S)?2?bromo?1?(4′?chlorophenyl)ethanol

: 1304788-11-1
(S)-1-(4-chlorophenyl)-2-phenoxyethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 2 h

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2.2: 24 h / 60 °C / Inert atmosphere

With sodium hydride; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jo102294j