2-(2-bromo-4,5-dimethoxyphenyl)-1-<(methylsulfonyl)oxy>ethane

Base Information

• Chemical Name: 2-(2-bromo-4,5-dimethoxyphenyl)-1-<(methylsulfonyl)oxy>ethane
• CAS No.: 149759-82-0
• Molecular Formula: C₁₁H₁₅BrO₅S
• Molecular Weight: 339.207
• Mol file: 149759-82-0.mol

Synonyms:2-(2-bromo-4,5-dimethoxyphenyl)-1-<(methylsulfonyl)oxy>ethane

Chemical Property of 2-(2-bromo-4,5-dimethoxyphenyl)-1-<(methylsulfonyl)oxy>ethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-bromo-4,5-dimethoxyphenyl)-1-<(methylsulfonyl)oxy>ethane

There total 3 articles about 2-(2-bromo-4,5-dimethoxyphenyl)-1-<(methylsulfonyl)oxy>ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(2-bromo-4,5-dimethoxyphenyl)ethyl alcohol (289507-36-4) + methanesulfonyl chloride (124-63-0) → 2-(2-bromo-4,5-dimethoxyphenyl)-1-<(methylsulfonyl)oxy>ethane (149759-82-0)

Guidance literature:

With triethylamine; In dichloromethane; Inert atmosphere; Cooling with ice;

DOI:10.1016/j.tet.2009.03.085

Reference yield:

Acetic acid 2-(2-bromo-4,5-dimethoxy-phenyl)-ethyl ester (149400-77-1) → 2-(2-bromo-4,5-dimethoxyphenyl)-1-<(methylsulfonyl)oxy>ethane (149759-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / methanol / 0.5 h

2: Et₃N / CH₂Cl₂ / a) 0 deg C, 45 min, b) r.t., 30 min

With potassium carbonate; triethylamine; In methanol; dichloromethane;

DOI:10.1021/jo00068a052

Reference yield:

2-(3,4-dimethoxyphenyl)ethyl alcohol (7417-21-2) → 2-(2-bromo-4,5-dimethoxyphenyl)-1-<(methylsulfonyl)oxy>ethane (149759-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / 1 h

2: K₂CO₃ / methanol / 0.5 h

3: Et₃N / CH₂Cl₂ / a) 0 deg C, 45 min, b) r.t., 30 min

With bromine; potassium carbonate; triethylamine; In methanol; dichloromethane;

DOI:10.1021/jo00068a052

upstream raw materials:

2-(2-bromo-4,5-dimethoxyphenyl)ethyl alcohol

methanesulfonyl chloride

Acetic acid 2-(2-bromo-4,5-dimethoxy-phenyl)-ethyl ester

2-(3,4-dimethoxyphenyl)ethyl alcohol

Downstream raw materials:

3-(cyclohexylamino)-1-<2-(2-bromo-4,5-dimethoxyphenyl)ethyl>-5,6-dihydro-2-oxo-4H-indole

ethyl N-(2-bromo-4,5-dimethoxyphenethyl)-3,4-bis-(3,4-dimethoxyphenyl)-5-formylpyrrole-2-carboxylate