(Z)-ethyl 2-(2-cyano-3-mercapto-3-(phenylamino)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Base Information

• Chemical Name: (Z)-ethyl 2-(2-cyano-3-mercapto-3-(phenylamino)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
• CAS No.: 1286216-36-1
• Molecular Formula: C₂₁H₂₁N₃O₃S₂
• Molecular Weight: 427.548
• Mol file: 1286216-36-1.mol

Synonyms:(Z)-ethyl 2-(2-cyano-3-mercapto-3-(phenylamino)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Chemical Property of (Z)-ethyl 2-(2-cyano-3-mercapto-3-(phenylamino)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-ethyl 2-(2-cyano-3-mercapto-3-(phenylamino)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

There total 2 articles about (Z)-ethyl 2-(2-cyano-3-mercapto-3-(phenylamino)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

ethyl 2‐(2‐cyanoacetamido)‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐3‐carboxylate (380467-91-4) + phenyl isothiocyanate (103-72-0) → (Z)-ethyl 2-(2-cyano-3-mercapto-3-(phenylamino)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (1286216-36-1)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/ardp.201000165

Reference yield:

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) → (Z)-ethyl 2-(2-cyano-3-mercapto-3-(phenylamino)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (1286216-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 5 h / Reflux

2: potassium hydroxide / N,N-dimethyl-formamide / 20 °C

With potassium hydroxide; In N,N-dimethyl-formamide; benzene;

DOI:10.1002/ardp.201000165

Reference yield: 85.0%

(Z)-ethyl 2-(2-cyano-3-mercapto-3-(phenylamino)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (1286216-36-1) + chloroacetone (78-95-5) → (Z)-ethyl 2-(2-cyano-2-(4-methyl-3-phenylthiazol-2(3H)-ylidene)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (1286216-37-2)

Guidance literature:

In ethanol; N,N-dimethyl-formamide; for 6h; Reflux;

DOI:10.1002/ardp.201000165

upstream raw materials:

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

ethyl 2‐(2‐cyanoacetamido)‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐3‐carboxylate

phenyl isothiocyanate

Downstream raw materials:

(Z)-ethyl 2-(2-cyano-2-(4-oxo-3-phenylthiazolidin-2-ylidene)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

(Z)-ethyl 2-(2-cyano-2-(4-methyl-3-phenylthiazol-2(3H)-ylidene)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

(Z)-ethyl 2-(2-cyano-2-(4-p-tolyl-3-phenylthiazol-2(3H)-ylidene)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate