potassium 2,3,6-trifluorobenzoate

Base Information

• Chemical Name: potassium 2,3,6-trifluorobenzoate
• CAS No.: 1206164-22-8
• Molecular Formula: C₇H₂F₃O₂*K
• Molecular Weight: 214.185
• Mol file: 1206164-22-8.mol

Synonyms:potassium 2,3,6-trifluorobenzoate

Chemical Property of potassium 2,3,6-trifluorobenzoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of potassium 2,3,6-trifluorobenzoate

There total 1 articles about potassium 2,3,6-trifluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,3,6-trifluorobenzoic acid (2358-29-4) → potassium 2,3,6-trifluorobenzoate (1206164-22-8)

Guidance literature:

With potassium tert-butylate; In ethanol; at 20 ℃; for 1.5h;

DOI:10.1002/anie.200904916

Reference yield: 85.0%

2-iodopyridine (5029-67-4) + potassium 2,3,6-trifluorobenzoate (1206164-22-8) → 2-(2,3,6-trifluorophenyl)pyridine (1206164-31-9)

Guidance literature:

2-iodopyridine; potassium 2,3,6-trifluorobenzoate; With copper(l) iodide; 1,10-Phenanthroline; at 160 ℃; for 24h;

In N,N-dimethyl acetamide;

DOI:10.1021/ol303567t

Reference yield: 82.0%

3-iodopyridine (1120-90-7) + potassium 2,3,6-trifluorobenzoate (1206164-22-8) → 3-(2,3,6-trifluorophenyl)pyridine

Guidance literature:

With 1,10-phenanthroline functionalized MCM-41-immobilized copper(I) iodide complex; In N,N-dimethyl acetamide; at 20 - 160 ℃; for 24h; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1039/c7ra05711c

upstream raw materials:

2,3,6-trifluorobenzoic acid

Downstream raw materials:

2-(2,3,6-trifluorophenyl)pyridine

2-(3,6-difluoro-2-(pyridin-2-yl)phenyl)benzoxazole

2-(3,6-difluoro-2-(pyridin-2-yl)phenyl)-5-phenylbenzoxazole

5-tert-butyl-2-(3,6-difluoro-2-(pyridin-2-yl)phenyl)benzoxazole

Refernces

• 1、 Shang, Rui,Xu, Qing,Jiang, Yuan-Ye,Wang, Yan,Liu, Lei. "Pd-catalyzed decarboxylative cross coupling of potassium polyfluorobenzoates with aryl bromides, chlorides, and triflates". supporting information; experimental part. p. 1000 - 1003. Retrieved 2010/06/16.