C₁₆H₁₂Br₂O₃

Base Information

• Chemical Name: C₁₆H₁₂Br₂O₃
• CAS No.: 1400055-34-6
• Molecular Formula: C₁₆H₁₂Br₂O₃
• Molecular Weight: 412.077
• Mol file: 1400055-34-6.mol

Synonyms:C₁₆H₁₂Br₂O₃

Chemical Property of C₁₆H₁₂Br₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₂Br₂O₃

There total 3 articles about C₁₆H₁₂Br₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C21H20Br2O5 (1400055-29-9) → C16H12Br2O3 (1400055-34-6)

Guidance literature:

C₂₁H₂₀Br₂O₅; With 9-O-benzylcupreidine; In toluene; at 23 ℃; for 48h; Reflux;

With toluene-4-sulfonic acid; In toluene; at 80 ℃; for 2h; enantioselective reaction;

DOI:10.1021/ol302273r DOI:10.1021/ol302273r

Reference yield:

3,4-dibromobenzaldehyde (74003-55-7) → C16H12Br2O3 (1400055-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: piperdinium acetate / benzene / 6 h / Reflux

2.1: 9-O-benzylcupreidine / toluene / 48 h / 23 °C / Reflux

2.2: 2 h / 80 °C

With 9-O-benzylcupreidine; piperdinium acetate; In toluene; benzene; 1.1: |Knoevenagel Condensation;

DOI:10.1021/ol302273r DOI:10.1021/ol302273r

Reference yield:

C14H18O5 (1351365-53-1) → C16H12Br2O3 (1400055-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: piperdinium acetate / benzene / 6 h / Reflux

2.1: 9-O-benzylcupreidine / toluene / 48 h / 23 °C / Reflux

2.2: 2 h / 80 °C

With 9-O-benzylcupreidine; piperdinium acetate; In toluene; benzene; 1.1: |Knoevenagel Condensation;

DOI:10.1021/ol302273r DOI:10.1021/ol302273r

upstream raw materials:

3,4-dibromobenzaldehyde

C₂₁H₂₀Br₂O₅

C₁₄H₁₈O₅

Downstream raw materials:

C₁₇H₁₄Br₂O₄

C₂₉H₃₈B₂O₈

C₃₄H₃₄O₁₂

C₃₃H₃₂O₁₂