2-(2-chlorobenzoylamido)phenylphosphonic acid diethyl ester

Base Information

• Chemical Name: 2-(2-chlorobenzoylamido)phenylphosphonic acid diethyl ester
• CAS No.: 1263913-95-6
• Molecular Formula: C₁₇H₁₉ClNO₄P
• Molecular Weight: 367.769
• Mol file: 1263913-95-6.mol

Synonyms:2-(2-chlorobenzoylamido)phenylphosphonic acid diethyl ester

Chemical Property of 2-(2-chlorobenzoylamido)phenylphosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(2-chlorobenzoylamido)phenylphosphonic acid diethyl ester

There total 5 articles about 2-(2-chlorobenzoylamido)phenylphosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(1H-benzo[d][1,2,3]triazol-1-yl)(2-chlorophenyl)methanone (30457-12-6) + triethyl phosphite (122-52-1) → 2-(2-chlorobenzoylamido)phenylphosphonic acid diethyl ester (1263913-95-6)

Guidance literature:

With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 10h; Irradiation;

DOI:10.1021/acs.orglett.8b02288

Reference yield: 38.0%

N-(2-bromophenyl)-2-chlorobenzamide (299954-54-4) + triethyl phosphite (122-52-1) → 2-(2-chlorobenzoylamido)phenylphosphonic acid diethyl ester (1263913-95-6)

Guidance literature:

With nickel dibromide; at 200 ℃; for 0.25h; Inert atmosphere;

DOI:10.1039/c0dt00881h

Reference yield:

1,2,3-Benzotriazole (95-14-7,27556-51-0) + o-chlorobenzoyl chloride (609-65-4) → 2-(2-chlorobenzoylamido)phenylphosphonic acid diethyl ester (1263913-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 10 h / 20 °C / Irradiation

With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

DOI:10.1021/acs.orglett.8b02288

upstream raw materials:

N-(2-bromophenyl)-2-chlorobenzamide

triethyl phosphite

o-chlorobenzoyl chloride

2-bromoaniline

Downstream raw materials:

2-(2-chlorophenyl)-1H-1,3-benzazaphosphole