Diphenyl-(2-phenyl-3H-imidazol-4-yl)-methanol; hydrochloride

Base Information

• Chemical Name: Diphenyl-(2-phenyl-3H-imidazol-4-yl)-methanol; hydrochloride
• CAS No.: 112655-27-3
• Molecular Formula: C₂₂H₁₈N₂O*ClH
• Molecular Weight: 362.859
• Mol file: 112655-27-3.mol

Synonyms:Diphenyl-(2-phenyl-3H-imidazol-4-yl)-methanol; hydrochloride

Chemical Property of Diphenyl-(2-phenyl-3H-imidazol-4-yl)-methanol; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diphenyl-(2-phenyl-3H-imidazol-4-yl)-methanol; hydrochloride

There total 3 articles about Diphenyl-(2-phenyl-3H-imidazol-4-yl)-methanol; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

[3-(1-Ethoxy-ethyl)-2-phenyl-3H-imidazol-4-yl]-diphenyl-methanol (112655-26-2) → Diphenyl-(2-phenyl-3H-imidazol-4-yl)-methanol; hydrochloride (112655-27-3)

Guidance literature:

With hydrogenchloride; In methanol; at 55 ℃; for 4h;

DOI:10.1021/jo00240a038

Reference yield:

2-Phenylimidazole (670-96-2) → Diphenyl-(2-phenyl-3H-imidazol-4-yl)-methanol; hydrochloride (112655-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, from -10 to 0 deg C, 30 min, 2.) from -20 deg C to RT, overnight

2: 1.) sec-BuLi / 1.) THF, -5 deg C, 30 min, 2.) from -5 deg C to RT, overnight

3: 77 percent / 0.1 N HCl / methanol / 4 h / 55 °C

With hydrogenchloride; n-butyllithium; sec.-butyllithium; In methanol;

DOI:10.1021/jo00240a038

Reference yield:

1-(1-Ethoxy-ethyl)-2-phenyl-1H-imidazole (112655-16-0) → Diphenyl-(2-phenyl-3H-imidazol-4-yl)-methanol; hydrochloride (112655-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sec-BuLi / 1.) THF, -5 deg C, 30 min, 2.) from -5 deg C to RT, overnight

2: 77 percent / 0.1 N HCl / methanol / 4 h / 55 °C

With hydrogenchloride; sec.-butyllithium; In methanol;

DOI:10.1021/jo00240a038

upstream raw materials:

[3-(1-Ethoxy-ethyl)-2-phenyl-3H-imidazol-4-yl]-diphenyl-methanol

2-Phenylimidazole

1-(1-Ethoxy-ethyl)-2-phenyl-1H-imidazole