670-96-2

Basic information

• Product Name: 2-Phenylimidazole
• Synonyms: 2-phenyl-1h-imidazol;2-PHENYLIMIDAZOLE;2-PHENYL-1H-IMIDAZOLE;TIMTEC-BB SBB004131;2-PHENYLIMIDAZOLE 90%;2-Phenylimidazole,>99%;2-Phenylimidazole,98%;1H-Imidazole, 2-phenyl-
• CAS NO: 670-96-2
• Molecular Formula: C₉H₈N₂
• Molecular Weight: 144.17
• EINECS: 211-581-7
• Product Categories: Industrial/Fine Chemicals;Imidazoles;Imidaxoles;Building Blocks;Heterocyclic Building Blocks;OLED materials,pharm chemical,electronic
• Mol File: 670-96-2.mol
• Article Data: 96

Chemical Properties

• Melting Point: 142-148 °C(lit.)
• Boiling Point: 340 °C
• Flash Point: 200 °C
• Appearance: Light yellow to beige/Powder, Granular or Crystalline Powder
• Density: 0.6 g/cm3
• Vapor Pressure: 0.000174mmHg at 25°C
• Refractive Index: 1.6025 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: Solubility in methanol (almost transparency).
• PKA: 13.00±0.10(Predicted)
• BRN: 114011
• CAS DataBase Reference: 2-Phenylimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenylimidazole(670-96-2)
• EPA Substance Registry System: 2-Phenylimidazole(670-96-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-21/22
• Safety Statements: 26-36-36/37
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 670-96-2(Hazardous Substances Data)

Usage

Chemical Properties

colorless to beige chunks or granular powder

Uses

Different sources of media describe the Uses of 670-96-2 differently. You can refer to the following data:
1. 2-Phenylimidazole (2-PI) is used to prepare complex compounds with ruthenium (III) and also as an intermediate for agrochemical, pharmaceutical and specialty products. It also finds its application as a curing agent for epoxy resins and polyurethane.
2. 2-Phenylimidazole is used to prepare complex compounds with ruthenium(III) and also as an intermediate for agrochemical, pharmaceutical and specialty products. It also finds its application as a curing agent for epoxy resins and polyurethane.

Synthesis Reference(s)

Tetrahedron, 63, p. 2414, 2007 DOI: 10.1016/j.tet.2007.01.014

InChI:InChI=1/C9H8N2/c1-2-4-8(5-3-1)9-10-6-7-11-9/h1-7H,(H,10,11)

Synthetic route

2-phenyl-1-tosyl-1H-imidazole → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With caesium carbonate In tetrahydrofuran; methanol at 22℃; for 0.5h;	100%
With lithium hydroxide; mercaptoacetic acid In N,N-dimethyl-formamide at 20℃; for 2.5h;	88%
With mercaptoacetic acid; lithium hydroxide In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	88%
With formic acid; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 24h; Inert atmosphere; Sealed tube; Irradiation;	80%
With cetyltrimethylammonim bromide; potassium hydroxide In tetrahydrofuran; water for 7h; Reflux; Green chemistry;

2-phenyl-imidazole-1-carboxylic acid benzyl ester → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With dimethylamine borane; potassium carbonate; triphenylphosphine; bis(triphenylphosphine)nickel(II) chloride In acetonitrile at 40℃; for 7h; Product distribution; Further Variations:; Catalysts; reaction times;	97%

2-phenyl-2-imidazoline (936-49-2) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With barium permanganate In dichloromethane for 24h; Heating;	96%
With potassium permanganate; montmorillonite K-10 In acetonitrile at 20℃; for 1h;	95%
With 1 wt percent Rh0 photodeposited TiO2 nanoparticles In isopropyl alcohol at 20℃; for 48h; Irradiation; Inert atmosphere; Sealed tube;	94%

2-phenyl-imidazole-1-carboxylic acid allyl ester → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With dimethylamine borane; caesium carbonate; triphenylphosphine; bis(triphenylphosphine)nickel(II) chloride In acetonitrile at 40℃;	96%

1-benzyl-2-phenyl-1H-imidazole (37734-89-7) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With potassium tert-butylate; oxygen; dimethyl sulfoxide at 25℃; for 0.25h;	94%
With triethylsilane; palladium 10% on activated carbon In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;	45%

2-chloro-1H-imidazole (16265-04-6) + phenylboronic acid (98-80-6) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate In water at 60℃; for 8h; Suzuki coupling;	92%
With potassium carbonate In ethanol; water at 50℃; for 4h; Suzuki-Miyaura coupling reaction; Inert atmosphere;	90%
With tetrabutylammomium bromide; potassium carbonate In water at 60℃; for 6h; Suzuki coupling;	90%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene at 60℃; for 3h;	68%

benzoyl chloride (98-88-4) + ethylenediamine (107-15-3) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With H6[PMo9V3O40] In acetonitrile at 90℃; for 2h;	90%

benzaldehyde (100-52-7) + ethylenediamine (107-15-3) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With tribromide-modified silica-coated magnetic nanoparticles (Fe3O4/SiO2/(CH2)3N+Me3Br3) In neat (no solvent) at 80℃; for 0.25h; Green chemistry;	90%

1H-imidazole (288-32-4) + iodobenzene (591-50-4) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With copper(l) iodide; palladium diacetate In N,N-dimethyl-formamide at 140℃; for 48h;	89%
With copper(l) iodide; magnesium oxide; triphenylphosphine; palladium diacetate In 1,4-dioxane at 150℃; for 12h;	83%
With copper(l) iodide; magnesium oxide; triphenylphosphine; palladium diacetate In 1,4-dioxane at 150℃; for 12h;	83%

(1H-imidazol-2-yl)boronic acid (1219080-61-1) + benzenesufonyl hydrazide (80-17-1) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tert-butyl methyl ether at 60℃; for 6h; Suzuki Coupling;	83%

1,1-dimethoxyethylene (922-69-0) + 2-Diazo-2H-imidazole (50846-98-5) → 2-Phenylimidazole (670-96-2) + 4,4-Dimethoxy-1,4-dihydro-imidazo[2,1-c][1,2,4]triazine (105851-05-6)

Conditions	Yield
In benzene Ambient temperature;	A n/a B 81%

Glyoxal (131543-46-9) + benzaldehyde (100-52-7) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With ammonium acetate; triethylammonium acetate In neat (no solvent) at 120℃; for 0.666667h;	78%
With ammonium acetate; lipase In water at 45℃; for 1h; Solvent; Time; Enzymatic reaction;	70%
With ammonium hydroxide In ethanol; water at 0℃; for 0.5h;	38%

1-tosyl-2-phenyl-Δ2-imidazoline (16054-55-0) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
Stage #1: 1-tosyl-2-phenyl-Δ2-imidazoline In tetrahydrofuran at -78℃; for 2h; Stage #2: With oxygen In tetrahydrofuran at 20℃;	68%

N-hydroxybenzenecarboximidamide (613-92-3) + trimethylsilylacetylene (1066-54-2) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide at 100℃; for 24h; Sealed tube; regioselective reaction;	67%

2-Diazo-2H-imidazole (50846-98-5) + benzene (71-43-2) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
Irradiation;	65%

5-phenyl-1-vinyl-1H-tetrazole (79866-76-5) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
In ethanol; trifluoroacetic acid for 2.5h; Irradiation;	61%

5-phenyl-1-vinyl-1H-tetrazole (79866-76-5) → 2-Phenylimidazole (670-96-2) + 5,6-dihydro-tetrazolo[5,1-a]isoquinoline (51687-24-2)

Conditions	Yield
In ethanol; trifluoroacetic acid Irradiation;	A 61% B n/a

2-phenylimidazole-1-carboxylic acid tert-butyl ester → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With 3-methoxypropylamine In tetrahydrofuran at 50℃; Sealed tube;	55%

(3aα,4α,7α,7aα)-2-phenyl-3a,4,7,7a-tetrahydro-4,7-methano-1H-benzimidazole → 2-Phenylimidazole (670-96-2)

Conditions	Yield
In decalin at 195℃; for 2h;	54%

1H-imidazole (288-32-4) + aniline (62-53-3) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
Stage #1: aniline With hydrogenchloride; sodium nitrite In water at 0 - 10℃; Stage #2: 1H-imidazole With sodium acetate at 5 - 20℃;	47.07%
Stage #1: aniline With hydrogenchloride; sodium azide In water at 0 - 10℃; Stage #2: 1H-imidazole With sodium acetate In water at 5 - 20℃; for 51h;

1H-imidazole (288-32-4) + C16H16F3IO6S → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With sodium hydroxide In neat (no solvent) at 110℃; for 10h;	44%

2-(4-fluorophenyl)-1H-imidazole (4278-08-4) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With 2-methyl-propan-1-ol; methanesulfonato(2-dicyclohexylphosphino -2’,6’-di-i-propoxy-1,1‘-biphenyl)(2’-amino-1,1’-biphenyl-2-yl)palladium(II); sodium tert-pentoxide In toluene at 80℃; for 96h; Sealed tube; Inert atmosphere;	41%

Glyoxal (131543-46-9) + (S)-2-Amino-1-phenyl-1-ethanol (56613-81-1) + benzaldehyde (100-52-7) → (S)-2-(1H-imidazol-1-yl)-1-phenylethanol + (S)-1-Phenyl-2-(2-phenyl-imidazol-1-yl)-ethanol + 2-Phenylimidazole (670-96-2)

Conditions	Yield
With ammonium acetate In methanol; water for 5h; Heating;	A n/a B 40% C n/a

C16H13N3O2 → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With hydrazine In 1,4-dioxane; water for 0.166667h; Inert atmosphere; UV-irradiation;	10%

imidazole-2-thione (872-35-5) + phenylboronic acid (98-80-6) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With copper(I)-thiophene-2-carboxylate; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 100℃; under 1500.15 - 2250.23 Torr; for 1h; microwave irradiation;	8%
With copper(I) thiophene-2-carboxylate; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 100℃; for 2h; microwave irradiation;	8%

2-phenylpyrimidine (7431-45-0) → 2-Phenylimidazole (670-96-2) + 2-phenylpyrimidine N-oxide (78009-13-9) + benzoic acid (65-85-0)

Conditions	Yield
With dihydrogen peroxide; acetic acid at 70℃; for 6h;	A 6% B 5% C 2%

2-phenyl-1,3-oxazole-4-carboxylic acid (23012-16-0) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With ammonium hydroxide at 200℃;

2-phenyl-1H-imidazole-4,5-dicarboxylic acid (888-60-8) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
bei der Destillation;

α-(benzylideneamino)acetonitrile (34039-84-4) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
at 0℃;

2,2-diethoxy-ethanamine (645-36-3) + methyl benzimidate (7471-86-5) → 2-Phenylimidazole (670-96-2)

Conditions	Yield
With acetic acid anschliessendes Erwaermen mit wss. HCl;

2-Phenylimidazole (670-96-2) + ethyl bromide (74-96-4) → 1-ethyl-2-phenyl-1H-imidazole (56468-46-3)

Conditions	Yield
Stage #1: 2-Phenylimidazole With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: ethyl bromide In tetrahydrofuran at 25℃; for 12h;	100%
Stage #1: 2-Phenylimidazole With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.333333h; Inert atmosphere; Stage #2: ethyl bromide In N,N-dimethyl-formamide at 25℃; for 12h; Inert atmosphere;	100%
Stage #1: 2-Phenylimidazole With sodium hydride In N,N-dimethyl acetamide for 0.25h; Green chemistry; Stage #2: ethyl bromide In N,N-dimethyl acetamide for 12h; Green chemistry;	98%
With sodium ethanolate In ethanol for 4h; Heating;	66%

2-Phenylimidazole (670-96-2) + 3,6,9-trioxadecyl bromide (72593-77-2) → 1-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)-2-phenyl-1H-imidazole

Conditions	Yield
With potassium hydroxide In acetonitrile at 20℃; for 24h;	100%

2-Phenylimidazole (670-96-2) + 4-bromobutanenitrile (5332-06-9) → 4-(2-phenyl-1H-imidazol-1-yl)butanenitrile (198549-12-1)

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide	99%
Stage #1: 2-Phenylimidazole With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h; Stage #2: 4-bromobutanenitrile In N,N-dimethyl-formamide at 20℃;	99%
Stage #1: 2-Phenylimidazole With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere; Stage #2: 4-bromobutanenitrile In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;

2-Phenylimidazole (670-96-2) + 5-bromopentan-1-nitrile (5414-21-1) → 5-(2-phenylimidazol-1-yl)valeronitrile (791856-78-5)

Conditions	Yield
Stage #1: 2-Phenylimidazole With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h; Stage #2: 5-bromopentan-1-nitrile In N,N-dimethyl-formamide at 20℃;	99%

2-Phenylimidazole (670-96-2) → 4,5-dibromo-2-phenyl-1H-imidazole (56338-00-2)

Conditions	Yield
With N-Bromosuccinimide In tetrahydrofuran at 0 - 20℃; for 1h;	99%
With bromine; potassium hydrogencarbonate; N,N-dimethyl-formamide In acetate buffer at 0 - 100℃; for 3h;	76%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere; Darkness;	72%

2-Phenylimidazole (670-96-2) → C9H4(2)H4N2

Conditions	Yield
With copper(l) iodide; tris(triphenylphosphine)ruthenium(II) chloride; potassium deuterohydroxide; water-d2 In 1,4-dioxane at 80℃; for 16h; Inert atmosphere; Schlenk technique; chemoselective reaction;	99%
With deuterium In tetrahydrofuran under 1500.15 Torr; for 12h; Glovebox; Heating;	30%

2-Phenylimidazole (670-96-2) + acrylic acid methyl ester (292638-85-8) → methyl 3-(2-phenyl-1H-imidazol-1-yl)propanoate

Conditions	Yield
In neat (no solvent) at 80℃; Michael Addition; Schlenk technique; Sealed tube;	99%

2-Phenylimidazole (670-96-2) + 3-methyltetrahydro-2-furanone (1679-47-6) → 2-methyl-4-(2-phenylimidazol-1-yl)butanoic acid (198549-11-0)

Conditions	Yield
Stage #1: 2-Phenylimidazole With potassium hydride Stage #2: 3-methyltetrahydro-2-furanone at 160 - 170℃; for 3h;	98%
With potassium hydride	80%

2-Phenylimidazole (670-96-2) + methyl iodide (74-88-4) → N-methyl-2-phenyl-1H-imidazole (3475-07-8)

Conditions	Yield
With sodium hydroxide; tetra-(n-butyl)ammonium iodide In toluene at 20℃; for 0.25h;	97%
With potassium hydroxide In 1,2-dimethoxyethane at 8℃; for 0.5h;	90%
Stage #1: 2-Phenylimidazole With n-butyllithium In tetrahydrofuran at 0℃; for 0.5h; Cooling with ice; Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 3h;	69%

2-Phenylimidazole (670-96-2) → 2-(4-nitrophenyl)imidazole (1614-06-8)

Conditions	Yield
Stage #1: 2-Phenylimidazole With tert-butyl methyl ether; nitric acid In tetrahydrofuran at 0℃; Stage #2: With sulfuric acid In dichloromethane at 0℃; for 1h; Further stages.;	95%
With sodium nitrate In neat (no solvent) at 20℃; for 0.5h; Green chemistry; regiospecific reaction;	92%
With sodium nitrate; sulfuric acid at 95℃; for 0.5h;	63%

4-butanolide (96-48-0) + 2-Phenylimidazole (670-96-2) → 4-(2-phenylimidazol-1-yl)butanoic acid (198549-10-9)

Conditions	Yield
With potassium hydride	95%
Stage #1: 2-Phenylimidazole With potassium hydride Stage #2: 4-butanolide at 160 - 170℃; for 3h;	95%

2-Phenylimidazole (670-96-2) + carbonic acid dimethyl ester (616-38-6) → N-methyl-2-phenyl-1H-imidazole (3475-07-8)

Conditions	Yield
With 18-crown-6 ether; potassium carbonate at 100℃; for 10h;	94%
With dmap In N,N-dimethyl-formamide at 80℃; for 6h;	70%
at 170℃; for 9h;	38%

2-Phenylimidazole (670-96-2) → 2-(2,6-dideuterophenyl)imidazole

Conditions	Yield
With triphenylphosphine(1,5-cyclooctadiene)[1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene]iridium(I) hexafluorophosphate; deuterium In dichloromethane at 25℃; under 760.051 Torr; for 1h; Reagent/catalyst; Sealed tube;	94%
With C34H43IrN3(1+)*F6P(1-); deuterium In dichloromethane at -78℃; for 16h; Reagent/catalyst; Inert atmosphere;	90%
With copper(l) iodide; tris(triphenylphosphine)ruthenium(II) chloride; water-d2; zinc In 1,4-dioxane at 80℃; for 16h; Inert atmosphere; Schlenk technique; chemoselective reaction;	41%

2-Phenylimidazole (670-96-2) + 1,2-dibromobenzene (583-53-9) → imidazo[1,2-f]phenanthridine (37694-95-4)

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 20 - 140℃; for 24h; Inert atmosphere; Schlenk technique; regioselective reaction;	94%
With palladium diacetate; potassium carbonate; tricyclohexylphosphine In N,N-dimethyl acetamide at 170℃; for 9h; Inert atmosphere;	55 %Chromat.
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In N,N-dimethyl-formamide

2-Phenylimidazole (670-96-2) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → N-methyl-2-phenyl-1H-imidazole (3475-07-8)

Conditions	Yield
In N,N-dimethyl-formamide at 80℃; for 2h; Temperature;	93.1%

2-Phenylimidazole (670-96-2) + dibutyltin chloride (683-18-1) → dichlorodibutylbis(2-phenylimidazole)tin(IV) (220335-28-4)

Conditions	Yield
In diethyl ether; ethanol N2-atmosphere; stirring (room temp., 6 h); filtering, washing (Et2O), drying (vac., 20°C, 0.1 Torr); elem. anal.;	93%

2-Phenylimidazole (670-96-2) + palladium dichloride → dichlorobis(2-phenyl-1H-imidazole)palladium(II) (1040403-31-3)

Conditions	Yield
In N,N-dimethyl-formamide to a suspn. of PdCl2 in DMF was added 2-phenylimidazole under Ar, the mixt. was stirred at 50°C for 2 h; the soln. was diluted with DMF, toluene was added, ppt. was filtered, washed with toluene and dried in air; elem. anal.;	93%

2-Phenylimidazole (670-96-2) + diphenyl acetylene (501-65-5) → 5,6-diphenylimidazo[2,1-a]isoquinoline (38147-72-7)

Conditions	Yield
With {(η5-pentamethylcyclopentadienyl)cobalt(I)2}2; silver(I) acetate; sodium acetate In 2,2,2-trifluoroethanol at 60℃; for 12h; Catalytic behavior; Reagent/catalyst; Temperature; Inert atmosphere;	93%
With (p-cymene)ruthenium(II) chloride; p-benzoquinone In N,N-dimethyl-formamide at 130℃; for 48h; Reagent/catalyst; Inert atmosphere;	88%
With potassium tert-butylate; nickel diacetate; 4,4'-di-tert-butyl-2,2'-bipyridine In toluene at 160℃; for 20h;	81%
With 1,2,3,4-tetraphenylcyclopentadiene; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate In N,N-dimethyl-formamide at 80℃; for 3h;	76%
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; 2,3,4,5-tetraphenylcyclopenta-2,4-dienone In N,N-dimethyl-formamide at 80℃; for 20h;	63%

2-Phenylimidazole (670-96-2) + bromobenzene (108-86-1) → 1,2-diphenylimidazole (52179-66-5)

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In N,N-dimethyl-formamide at 150℃; Inert atmosphere;	92%
With copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline; caesium carbonate; ethylene glycol; poly(ethylene glycol) In various solvent(s) at 120℃; for 72h;	90%
With 4,7-dimethoxy-1,10-phenanthroline; caesium carbonate; ethylene glycol; poly(ethylene glycol); copper(I) oxide In various solvent(s) at 120℃; for 72h;	90%

2-Phenylimidazole (670-96-2) → 2-phenyl-4,5-bis(hydroxymethyl)-imidazole (61698-32-6)

Conditions	Yield
With potassium hydroxide; paraformaldehyde In ethanol	92%

2-Phenylimidazole (670-96-2) + mercury dichloride → (1-chloromercury)-2-phenylimidazole (80345-89-7)

Conditions	Yield
In water aq. solns. of educts mixed under stirring; filtered, washed with water, EtOH and Et2O; elem. anal.;	92%

2-Phenylimidazole (670-96-2) + 1-iodo-butane (542-69-8) → 1-butyl-2-phenyl-1H-imidazole

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide at 25℃;	90%

2-Phenylimidazole (670-96-2) + formaldehyd (50-00-0) → 2-phenyl-4,5-bis(hydroxymethyl)-imidazole (61698-32-6)

Conditions	Yield
With potassium hydroxide In water	90%
With potassium hydroxide In water	86%
With sodium hydroxide In water	86%

2-Phenylimidazole (670-96-2) + phenyltin trichloride (1124-19-2) → trichlorobutylbis(2-phenylimidazole)tin(IV) (220335-31-9)

Conditions	Yield
In dichloromethane N2-atmosphere; stirring (room temp., 24 h); evapn., pptn. on Et2O addn., filtering, washing (Et2O), drying (vac., 20°C, 0.1 Torr); elem. anal.;	90%

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• 67097-50-1 Benzeneacetic acid, 4-(ethoxycarbonyl) 
• 67098-20-8 1-methyl-3-phenoxy-5-[3-(trifluoromethyl)phenyl]pyridin-4(1H)-one 
• 67098-29-7 4-Piperidinyl benzoate hydrochloride 
• 67098-31-1 1-(morpholin-4-yl)-2-(3-nitrophenyl)ethanethione 
• 670-98-4 METHYL BENZENESULFINATE 
• 67098-56-0 3-TERT-BUTOXYCARBONYLAMINO-2-PHENYL-PROPIONIC ACID 
• 67098-97-9 1-(chloromethyl)-4-fluoro-2-isocyanatobenzene 
• 67099-40-5 3,3-dimethylpent-4-ynoic acid 
• 67099-81-4 9,10,11,12-tetrahydrobenzo[e]pyrene 
• 67100-12-3 1,3-Dioxolane, 2-(5-hexynyl)- (9CI) 
• 671-01-2 N-benzyl-3-fluorobenzamide 
• 67101-29-5 6,7-Epoxyoctadecanoic acid methyl ester 

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