2-<3,4-bis(benzyloxy)phenyl>-1-chloroethane

Base Information

• Chemical Name: 2-<3,4-bis(benzyloxy)phenyl>-1-chloroethane
• CAS No.: 96826-06-1
• Molecular Formula: C₂₂H₂₁ClO₂
• Molecular Weight: 352.861
• Mol file: 96826-06-1.mol

Synonyms:2-<3,4-bis(benzyloxy)phenyl>-1-chloroethane

Chemical Property of 2-<3,4-bis(benzyloxy)phenyl>-1-chloroethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<3,4-bis(benzyloxy)phenyl>-1-chloroethane

There total 4 articles about 2-<3,4-bis(benzyloxy)phenyl>-1-chloroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-<3,4-bis(benzyloxy)phenyl>ethanol (96826-11-8) → 2-<3,4-bis(benzyloxy)phenyl>-1-chloroethane (96826-06-1)

Guidance literature:

With thionyl chloride; In tetrachloromethane; for 24h; Heating;

DOI:10.1021/jm00147a026

Reference yield: 57.0%

benzyl chloride (100-44-7) + 1-chloro-2-(3,4-dihydroxyphenyl)ethane (104693-00-7) → 2-<3,4-bis(benzyloxy)phenyl>-1-chloroethane (96826-06-1)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; for 15h; Heating;

DOI:10.1021/jm00384a038

Reference yield:

2-chloro-3',4'-dihydroxyacetophenone (99-40-1) → 2-<3,4-bis(benzyloxy)phenyl>-1-chloroethane (96826-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / CF₃COOH, Et₃SiH / Ambient temperature

2: 57 percent / K₂CO₃, NaI / acetone / 15 h / Heating

With triethylsilane; potassium carbonate; trifluoroacetic acid; sodium iodide; In acetone;

DOI:10.1021/jm00384a038

upstream raw materials:

2-<3,4-bis(benzyloxy)phenyl>ethanol

benzyl chloride

1-chloro-2-(3,4-dihydroxyphenyl)ethane

2-chloro-3',4'-dihydroxyacetophenone

Downstream raw materials:

1-<3,4-bis(benzyloxy)phenyl>-2-(methylseleno)ethane

N-<2-<3,4-bis(benzyloxy)phenyl>ethyl>ethylenediamine

N-<2-<3,4-bis(benzyloxy)phenyl>ethyl>imidazoline hydrochloride salt

N-<2-(3,4-dihydroxyphenyl)ethyl>imidazoline hydrochloride salt