ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-2-hydroxypropanoate

Base Information

Chemical Name:ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-2-hydroxypropanoate
CAS No.:1332315-27-1
Molecular Formula:C₁₆H₁₉N₃O₅
Molecular Weight:333.344
Hs Code.:

Synonyms:ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-2-hydroxypropanoate

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Chemical Property of ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-2-hydroxypropanoate

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Technology Process of ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-2-hydroxypropanoate

There total 4 articles about ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-2-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 924-44-7
glyoxylic acid ethyl ester

: 1332315-16-8
4-[4-(chloromethyl)phenyl]-1,2-dimethyl-5-nitro-1H-imidazole

: 1332315-27-1
ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-2-hydroxypropanoate

Guidance literature:: With Tetrakis(dimethylamino)ethylen; In N,N-dimethyl-formamide; at -20 - 20 ℃; for 25h; Inert atmosphere;
DOI:10.3390/molecules16086883

Reference yield:

: 1197836-54-6
[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]methanol

: 1332315-27-1
ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-2-hydroxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 16 h / 20 °C

2: Tetrakis(dimethylamino)ethylen / N,N-dimethyl-formamide / 25 h / -20 - 20 °C / Inert atmosphere

With thionyl chloride; Tetrakis(dimethylamino)ethylen; In N,N-dimethyl-formamide;
DOI:10.3390/molecules16086883

Reference yield:

: 59016-93-2
p-hydroxymethylphenylboronic acid

: 1332315-27-1
ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-2-hydroxypropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol / 1 h / Microwave irradiation

2: thionyl chloride / 16 h / 20 °C

3: Tetrakis(dimethylamino)ethylen / N,N-dimethyl-formamide / 25 h / -20 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; Tetrakis(dimethylamino)ethylen; sodium carbonate; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;
DOI:10.3390/molecules16086883