3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one

Base Information

• Chemical Name: 3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one
• CAS No.: 1247822-08-7
• Molecular Formula: C₁₅H₁₁BrF₂O₂
• Molecular Weight: 341.152
• Mol file: 1247822-08-7.mol

Synonyms:3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one

Chemical Property of 3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one

There total 11 articles about 3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

potassium 2,2-difluoro-3-oxo-3-phenylpropanoate + 4-bromo-benzaldehyde (1122-91-4) → 3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one (1247822-08-7)

Guidance literature:

With zinc dichloro(N,N,N′,N′-tetramethylethylenediamine); water; In tetrahydrofuran; at 80 ℃; for 5h; Inert atmosphere; Green chemistry;

DOI:10.1039/c8ra02440e

Reference yield: 82.0%

2,2-difluoro-3-oxo-3-phenylpropanoic acid + 4-bromo-benzaldehyde (1122-91-4) → 3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one (1247822-08-7)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; potassium carbonate; In 1,2-dimethoxyethane; at 80 ℃; for 10h; Inert atmosphere;

DOI:10.1039/c7ob01739a

Reference yield: 79.0%

p-bromo-N-(p-bromobenzylidene)aniline (62305-65-1) + 2,2-difluoro-1-phenyl-1-trimethylsiloxyethene (86340-78-5) → 3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one (1247822-08-7)

Guidance literature:

With water; zinc trifluoromethanesulfonate; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1016/j.tet.2010.07.034

upstream raw materials:

p-bromo-N-(p-bromobenzylidene)aniline

2,2-difluoro-1-phenyl-1-trimethylsiloxyethene

α-bromo-α,α-difluoro-acetophenone

4-bromo-benzaldehyde