tert-butyl [(3R)-1-{5-[(2-bromophenyl)carbamoyl]-1-(2-chlorobenzyl)-1H-imidazol-2-yl}piperidin-3-yl]carbamate

Base Information

Chemical Name:tert-butyl [(3R)-1-{5-[(2-bromophenyl)carbamoyl]-1-(2-chlorobenzyl)-1H-imidazol-2-yl}piperidin-3-yl]carbamate
CAS No.:1349877-52-6
Molecular Formula:C₂₇H₃₁BrClN₅O₃
Molecular Weight:588.932
Hs Code.:

Synonyms:tert-butyl [(3R)-1-{5-[(2-bromophenyl)carbamoyl]-1-(2-chlorobenzyl)-1H-imidazol-2-yl}piperidin-3-yl]carbamate

Suppliers and Price of tert-butyl [(3R)-1-{5-[(2-bromophenyl)carbamoyl]-1-(2-chlorobenzyl)-1H-imidazol-2-yl}piperidin-3-yl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl [(3R)-1-{5-[(2-bromophenyl)carbamoyl]-1-(2-chlorobenzyl)-1H-imidazol-2-yl}piperidin-3-yl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl [(3R)-1-{5-[(2-bromophenyl)carbamoyl]-1-(2-chlorobenzyl)-1H-imidazol-2-yl}piperidin-3-yl]carbamate

There total 9 articles about tert-butyl [(3R)-1-{5-[(2-bromophenyl)carbamoyl]-1-(2-chlorobenzyl)-1H-imidazol-2-yl}piperidin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₆Cl₂N₄O₃

: 615-36-1
2-bromoaniline

: 1349877-52-6
tert-butyl [(3R)-1-{5-[(2-bromophenyl)carbamoyl]-1-(2-chlorobenzyl)-1H-imidazol-2-yl}piperidin-3-yl]carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In toluene; at 100 ℃; for 4h;
DOI:10.1016/j.tet.2011.10.015

Reference yield:

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

: 1349877-52-6
tert-butyl [(3R)-1-{5-[(2-bromophenyl)carbamoyl]-1-(2-chlorobenzyl)-1H-imidazol-2-yl}piperidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: isopropyl alcohol / 2.5 h / 20 °C

1.2: 6 h / 0 - 80 °C

2.1: potassium carbonate / acetonitrile / 72 h / 40 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 0 - 15 °C

4.1: diiodomethane; isopentyl nitrite / toluene / 9 h / 80 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

6.1: sodium hydroxide / tetrahydrofuran; ethanol / 5 h / 80 °C

7.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / toluene / 4 h / 100 °C

With oxalyl dichloride; diiodomethane; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; isopentyl nitrite; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile; mineral oil; 4.1: Sandmeyer reaction;
DOI:10.1016/j.tet.2011.10.015

Reference yield:

: 1349877-51-5
2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-1H-imidazole-5-carboxylic acid

: 1349877-52-6
tert-butyl [(3R)-1-{5-[(2-bromophenyl)carbamoyl]-1-(2-chlorobenzyl)-1H-imidazol-2-yl}piperidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / toluene / 4 h / 100 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2011.10.015