2-bromo-2,2-difluoro-N-(4-fluoro-2-hydroxyphenyl)acetamide

Base Information

• Chemical Name: 2-bromo-2,2-difluoro-N-(4-fluoro-2-hydroxyphenyl)acetamide
• CAS No.: 1258836-73-5
• Molecular Formula: C₈H₅BrF₃NO₂
• Molecular Weight: 284.032
• Mol file: 1258836-73-5.mol

Synonyms:2-bromo-2,2-difluoro-N-(4-fluoro-2-hydroxyphenyl)acetamide

Chemical Property of 2-bromo-2,2-difluoro-N-(4-fluoro-2-hydroxyphenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-2,2-difluoro-N-(4-fluoro-2-hydroxyphenyl)acetamide

There total 4 articles about 2-bromo-2,2-difluoro-N-(4-fluoro-2-hydroxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

Ethyl bromodifluoroacetate (667-27-6) + 2-amino-5-fluorophenol (53981-24-1) → 2-bromo-2,2-difluoro-N-(4-fluoro-2-hydroxyphenyl)acetamide (1258836-73-5)

Guidance literature:

2-amino-5-fluorophenol; With sodium hydride; In tetrahydrofuran; mineral oil; at -15 ℃; for 0.5h; Inert atmosphere;

Ethyl bromodifluoroacetate; In tetrahydrofuran; mineral oil; at 0 ℃; for 2h;

Reference yield:

bromodifluoroacetyl chloride (3832-48-2) + 2-amino-5-fluorophenol (53981-24-1) → 2-bromo-2,2-difluoro-N-(4-fluoro-2-hydroxyphenyl)acetamide (1258836-73-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 100 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

methyl bromodifluoroacetate (683-98-7) + 2-amino-5-fluorophenol (53981-24-1) → 2-bromo-2,2-difluoro-N-(4-fluoro-2-hydroxyphenyl)acetamide (1258836-73-5)

Guidance literature:

methyl bromodifluoroacetate; 2-amino-5-fluorophenol; With sodium hydride; In tetrahydrofuran; mineral oil; at -15 - 0 ℃;

With ammonium chloride; In tetrahydrofuran; water; mineral oil;

upstream raw materials:

methyl bromodifluoroacetate

2-amino-5-fluorophenol

Ethyl bromodifluoroacetate

bromodifluoroacetyl chloride

Downstream raw materials:

phenyl N-[2,2,7-trifluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl]carbamate