683-98-7

Basic information

• Product Name: METHYL BROMODIFLUOROACETATE
• Synonyms: METHYL BROMODIFLUOROACETATE;Bromo(difluoro)acetic acid methyl ester;Methyl 2-broMo-2,2-difluoroacetate;Bromo(difluoro)acetic acid methyl ester, Methyl 2-bromo-2,2-difluoroethanoate
• CAS NO: 683-98-7
• Molecular Formula: C₃H₃BrF₂O₂
• Molecular Weight: 188.96
• Mol File: 683-98-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 97-98°C
• Flash Point: 6.6°C
• Appearance: /
• Density: 1.7125 g/cm3 (23℃)
• Vapor Pressure: 64.1mmHg at 25°C
• Refractive Index: 1.3880 (589.3 nm 23℃)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL BROMODIFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL BROMODIFLUOROACETATE(683-98-7)
• EPA Substance Registry System: METHYL BROMODIFLUOROACETATE(683-98-7)

Safety Data

• Hazard Codes: Xi
• RIDADR: 2924
• HazardClass: IRRITANT
• PackingGroup: II
• Hazardous Substances Data: 683-98-7(Hazardous Substances Data)

Usage

General Description

Methyl bromodifluoroacetate is a chemical compound with the formula C3H2BrF2O2. It is a colorless, odorless liquid and is commonly used as a reagent in organic synthesis. Methyl bromodifluoroacetate is an important intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used in the manufacture of fluoroorganic compounds. METHYL BROMODIFLUOROACETATE is highly reactive and should be handled with care, as it can cause skin and eye irritation, and can be harmful if swallowed, inhaled, or absorbed through the skin. It is also a potential environmental hazard and should be disposed of properly.

InChI:InChI=1/C3H3BrF2O2/c1-8-2(7)3(4,5)6/h1H3

Upstream product

• 100-39-0 benzyl bromide 
• 109872-87-9 methyl difluoroiodoacetate 
• 67-56-1 methanol 
• 3832-48-2 bromodifluoroacetyl chloride 
• 123771-68-6 poly-{(methyl difluoroacetate)copper} 
• 37746-78-4 4-bromo-trans-crotonic acid ethyl ester 
• 107-31-3 Methyl formate 
• 430-85-3 1,1-dibromo-2,2-difluoroethylene 
• 3222-05-7 methyl tribromoacetate 
• 558-57-6 1,2-dibromo-1,1-dichloro-2,2-difluoroethane 
• 84509-61-5 2-((4-bromobut-3-yn-1-yl)oxy)-tetrahydro-2H-pyran 
• 124745-25-1 1,1-difluoro-2,2-diphenylthioethylene 

Downstream Products

• 401-75-2 trifluoromethylcyclohexane 
• 120316-00-9 (S)-1-Benzyl-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-azetidin-2-one 
• 120316-01-0 (R)-1-Benzyl-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-azetidin-2-one 
• 120316-05-4 1-Benzyl-3,3-difluoro-4-((E)-propenyl)-azetidin-2-one 
• 89942-12-1 (E)/(Z)-1-bromo-1-heptene 
• 109872-88-0 (E)-2,2-Difluoro-non-3-enoic acid methyl ester 
• 120316-04-3 3,3-Difluoro-4-phenyl-1-((S)-1-phenyl-ethyl)-azetidin-2-one 
• 2314-97-8 iodotrifluoromethane 
• 74-88-4 methyl iodide 
• 1184-76-5 difluorodiiodomethane 
• 120316-02-1 1-phenyl-3,3-difluoro-4-phenyl-2-azetidinone 
• 420-46-2 2,2,2-trifluoroethanol 
• 651-94-5 α,α,α-trifluoro-2,4,6-trinitrotoluene 

Relevant articles and documents

-

-

Ozone oxidation process of preparing a halogenated acetic acid and esters thereof (by machine translation)

The invention belongs to the field of chemical synthesis, in particular to a halogenated acetic acid or a halogenated acetic acid ester compound preparation method; halogenated ethane (type I) by ozone oxidation after the reaction, the reaction with water or alcohol to obtain a halogenated acetic acid or halogenated acetate (type II). (by machine translation)

(METHYL DIFLUOROACETATE)COPPER REAGENT. REMARKABLE SOLVENT EFFECT ON THE 19F-NMR SPECTRUM, STABILITY AND REACTIVITY

The 19F-NMR spectrum, thermal stability and reactivity of (methyl difluoroacetate)copper reagent were found to differ remarkably depending on the solvent (DMSO, DMF, or HMPA) used.With allylic bromide or alkynyl halide a crucial solvent effect for the coupling reactions was observed.