4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene

Base Information

• Chemical Name: 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene
• CAS No.: 150501-75-0
• Molecular Formula: C₂₄H₄₆O₂Si₂
• Molecular Weight: 422.799
• Mol file: 150501-75-0.mol

Synonyms:4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene

Chemical Property of 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene

There total 4 articles about 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

triisopropylsilyl chloride (13154-24-0) + 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-(hydroxymethyl)benzene (150501-77-2) → 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene (150501-75-0)

Guidance literature:

In acetonitrile;

DOI:10.1021/jo00071a023

Reference yield:

ethyl-4-acetylbenzoate (38430-55-6) → 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene (150501-75-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / NaBH₄ / ethanol / 0.5 h / Heating

2: 96 percent / acetonitrile

3: 87 percent / LiAlH₄ / diethyl ether / 3 h / Heating

4: 93 percent / acetonitrile

With sodium tetrahydroborate; lithium aluminium tetrahydride; In diethyl ether; ethanol; acetonitrile;

DOI:10.1021/jo00071a023

Reference yield:

4-[1-hydroxyethyl]benzoic acid ethyl ester (107751-31-5) → 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene (150501-75-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / acetonitrile

2: 87 percent / LiAlH₄ / diethyl ether / 3 h / Heating

3: 93 percent / acetonitrile

With lithium aluminium tetrahydride; In diethyl ether; acetonitrile;

DOI:10.1021/jo00071a023

upstream raw materials:

triisopropylsilyl chloride

4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-(hydroxymethyl)benzene

ethyl-4-acetylbenzoate

4-[1-hydroxyethyl]benzoic acid ethyl ester

Downstream raw materials:

4-(1-hydroxyethyl)benzyl alcohol

4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-(hydroxymethyl)benzene