150501-77-2

Upstream product

• 150501-70-5 Ethyl 4-<1-(tert-butyldimethylsiloxy)ethyl>benzoate 
• 150501-75-0 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene 
• 38430-55-6 ethyl-4-acetylbenzoate 
• 107751-31-5 4-[1-hydroxyethyl]benzoic acid ethyl ester 
• 1174669-38-5 1-(tert-butyldimethylsilyloxymethyl)-4-(1'-(tert-butyldimethylsilyloxy)ethyl)benzene 

Downstream Products

• 80463-22-5 4-(1-hydroxyethyl)benzyl alcohol 
• 150501-75-0 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene 

Relevant academic research and scientific papers

Fluorous TBAF: A convenient and selective reagent for fluoride-mediated deprotections

(Chemical Equation Presented) A fluorous analogue of TBAF has been developed for its use in the clean removal of silicon-derived protecting groups. Purification of the crude mixtures by fluorous solid-phase extractions allowed alcohols, amines, and carboxylic acids to be obtained in high purity, with no need of chromatographic separations. The moderate reactivity of fluorous TBAF was exploited in selective deprotections of several bifunctional molecules.

Improved Protocols for the Selective Deprotection of Trialkylsilyl Ethers Using Fluorosilicic Acid

Improvements for the application of aqueous fluorosilicic acid to the selective cleavage of tert-butyldimethylsilyl ethers in the presence of triisopropylsilyl ethers are described.Deprotection conditions have been optimized for cleavage selectivity, tole