1-(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-2-(2,4-dichlorophenyl)ethanone

Base Information

Chemical Name:1-(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-2-(2,4-dichlorophenyl)ethanone
CAS No.:1345823-36-0
Molecular Formula:C₁₇H₁₂Cl₂N₄O₃
Molecular Weight:391.213
Hs Code.:

Synonyms:1-(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-2-(2,4-dichlorophenyl)ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-2-(2,4-dichlorophenyl)ethanone

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Technology Process of 1-(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-2-(2,4-dichlorophenyl)ethanone

There total 3 articles about 1-(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-2-(2,4-dichlorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1345823-24-6
1-(2,4-dichlorophenyl)-4-(trimethylsilyl)but-3-yn-2-one

: 17271-88-4
p-nitrobenzyl azide

: 1345823-36-0
1-(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-2-(2,4-dichlorophenyl)ethanone

Guidance literature:: With sodium L-ascorbate; copper dichloride; In water; acetonitrile; at 20 ℃; Reflux;
DOI:10.1016/j.ejmech.2011.09.013

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1345823-36-0
1-(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-2-(2,4-dichlorophenyl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 20 °C

2: sodium L-ascorbate; copper dichloride / water; acetonitrile / 20 °C / Reflux

With sodium azide; sodium L-ascorbate; copper dichloride; In water; N,N-dimethyl-formamide; acetonitrile; 2: Huisgen cycloaddition;
DOI:10.1016/j.ejmech.2011.09.013

Reference yield:

: 19719-28-9
2,4-dichlorophenylacetic acid

: 1345823-36-0
1-(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-2-(2,4-dichlorophenyl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / Reflux

2: aluminum (III) chloride / dichloromethane / 0 °C

3: sodium L-ascorbate; copper dichloride / water; acetonitrile / 20 °C / Reflux

With aluminum (III) chloride; thionyl chloride; sodium L-ascorbate; copper dichloride; In dichloromethane; water; acetonitrile; 3: Huisgen cycloaddition;
DOI:10.1016/j.ejmech.2011.09.013