Technology Process of 3-chloromethyl-5-phenylpyrazole hydrochloride
There total 4 articles about 3-chloromethyl-5-phenylpyrazole hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
thionyl chloride;
at 40 - 65 ℃;
for 2.16667h;
DOI:10.1021/jo026083e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h
1.2: ZnCl2 / tetrahydrofuran; hexane / 1 h / 0 °C
1.3: 49 percent / tetrahydrofuran; hexane / 0.5 h / 40 °C
2.1: 98 percent / hydrazine monohydrate / methanol / 1 h
3.1: 74 percent / aqueous hydrochloric acid / methanol / 3 h / pH 2
4.1: 95 percent / thionyl chloride / 2.17 h / 40 - 65 °C
With
hydrogenchloride; n-butyllithium; thionyl chloride; hydrazine hydrate;
In
tetrahydrofuran; methanol; hexane;
DOI:10.1021/jo026083e
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98 percent / hydrazine monohydrate / methanol / 1 h
2: 74 percent / aqueous hydrochloric acid / methanol / 3 h / pH 2
3: 95 percent / thionyl chloride / 2.17 h / 40 - 65 °C
With
hydrogenchloride; thionyl chloride; hydrazine hydrate;
In
methanol;
DOI:10.1021/jo026083e
