N-{2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2yl]-benzyl}acetamide

Base Information

Chemical Name:N-{2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2yl]-benzyl}acetamide
CAS No.:1176408-10-8
Molecular Formula:C₂₀H₁₆BrCl₂F₃N₂O
Molecular Weight:508.165
Hs Code.:

Synonyms:N-{2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2yl]-benzyl}acetamide

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Chemical Property of N-{2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2yl]-benzyl}acetamide

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Technology Process of N-{2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2yl]-benzyl}acetamide

There total 12 articles about N-{2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2yl]-benzyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1159792-41-2
2-bromo-4-[4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]benzylamine

: 108-24-7
acetic anhydride

: 1176408-10-8
N-{2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2yl]-benzyl}acetamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1174731-67-9
3-bromo-4-(2-oxopropyl)-N-trimethylsilanylmethylthiobenzamide

: 1176408-10-8
N-{2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2yl]-benzyl}acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 0 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere

3: sodium methylate; methanol / 1 h / 20 °C

4: triethylamine / tetrahydrofuran / 1 h / 20 °C

5: methanol; ammonium hydroxide / tetrahydrofuran / 12 h / 20 °C

6: tetrahydrofuran / 1 h / 20 °C

With methanol; ammonium hydroxide; tetrabutyl ammonium fluoride; sodium methylate; potassium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 7697-26-9
3-bromo-4-methylbenzoic acid

: 1176408-10-8
N-{2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2yl]-benzyl}acetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / Reflux

1.2: 1 h / 20 °C

2.1: silver nitrate / water; acetone / 6 h / 20 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

4.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.1: Lawessons reagent / tetrahydrofuran / 3 h / Reflux

6.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 0 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere

8.1: sodium methylate; methanol / 1 h / 20 °C

9.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

10.1: methanol; ammonium hydroxide / tetrahydrofuran / 12 h / 20 °C

11.1: tetrahydrofuran / 1 h / 20 °C

With Lawessons reagent; methanol; ammonium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; tetrabutyl ammonium fluoride; sodium methylate; potassium carbonate; silver nitrate; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; water; N,N-dimethyl-formamide; acetone;