1-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-[2-hydroxy-3,3-dimethyl-butyl]urea

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Chemical Name:1-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-[2-hydroxy-3,3-dimethyl-butyl]urea
CAS No.:1455031-66-9
Molecular Formula:C₂₄H₃₀FN₅O₂
Molecular Weight:439.533
Hs Code.:

Synonyms:1-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-[2-hydroxy-3,3-dimethyl-butyl]urea

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Chemical Property of 1-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-[2-hydroxy-3,3-dimethyl-butyl]urea

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Technology Process of 1-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-[2-hydroxy-3,3-dimethyl-butyl]urea

There total 15 articles about 1-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-[2-hydroxy-3,3-dimethyl-butyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1455036-94-8
prop-1-en-2-yl (2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)[1,6]naphthyridin-3-yl)phenyl)carbamate

: 1438-15-9
1-amino-3,3-dimethyl-butan-2-ol hydrochloride

: 1455031-66-9
1-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-[2-hydroxy-3,3-dimethyl-butyl]urea

Guidance literature:: With 1-Methylpyrrolidine; In 1,4-dioxane; at 90 ℃;
DOI:10.1021/acs.jmedchem.5b00067

Reference yield:

: 452-63-1
2-Bromo-5-fluorotoluene

: 1455031-66-9
1-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-[2-hydroxy-3,3-dimethyl-butyl]urea

Guidance literature:: Multi-step reaction with 7 steps

1: nitric acid; sulfuric acid / 0.83 h / -5 - 20 °C

2: hydrogen / ethanol / 2062.71 Torr

3: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 100 °C / Inert atmosphere

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 1 h / 60 °C / Inert atmosphere

5: ethanol / 7 h / 154 °C / Microwave irradiation

6: pyridine / 2 h / 20 °C / Cooling with ice

7: 1-Methylpyrrolidine / 1,4-dioxane / 90 °C

With 1-Methylpyrrolidine; pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; hydrogen; nitric acid; potassium acetate; potassium carbonate; In 1,4-dioxane; ethanol; water; 6: |Schotten-Baumann Reaction;
DOI:10.1021/acs.jmedchem.5b00067

Reference yield:

: 1455035-96-7
7-chloro-2-methyl[1,6]naphthyridin-3-yl trifluoromethanesulfonate

: 1455031-66-9
1-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-3-[2-hydroxy-3,3-dimethyl-butyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 1 h / 60 °C / Inert atmosphere

2: ethanol / 7 h / 154 °C / Microwave irradiation

3: pyridine / 2 h / 20 °C / Cooling with ice

4: 1-Methylpyrrolidine / 1,4-dioxane / 90 °C

With 1-Methylpyrrolidine; pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; ethanol; water; 3: |Schotten-Baumann Reaction;
DOI:10.1021/acs.jmedchem.5b00067