prop-1-en-2-yl (2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)[1,6]naphthyridin-3-yl)phenyl)carbamate

Base Information

Chemical Name:prop-1-en-2-yl (2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)[1,6]naphthyridin-3-yl)phenyl)carbamate
CAS No.:1455036-94-8
Molecular Formula:C₂₁H₂₁FN₄O₂
Molecular Weight:380.422
Hs Code.:

Synonyms:prop-1-en-2-yl (2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)[1,6]naphthyridin-3-yl)phenyl)carbamate

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Chemical Property of prop-1-en-2-yl (2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)[1,6]naphthyridin-3-yl)phenyl)carbamate

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Technology Process of prop-1-en-2-yl (2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)[1,6]naphthyridin-3-yl)phenyl)carbamate

There total 14 articles about prop-1-en-2-yl (2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)[1,6]naphthyridin-3-yl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 57933-83-2
Isopropenyl chloroformate

: 1455036-26-6
3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine

: 1455036-94-8
prop-1-en-2-yl (2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)[1,6]naphthyridin-3-yl)phenyl)carbamate

Guidance literature:: With pyridine; at 20 ℃; for 2h; Cooling with ice;
DOI:10.1021/acs.jmedchem.5b00067

Reference yield:

: 452-63-1
2-Bromo-5-fluorotoluene

: 1455036-94-8
prop-1-en-2-yl (2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)[1,6]naphthyridin-3-yl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: nitric acid; sulfuric acid / 0.83 h / -5 - 20 °C

2: hydrogen / ethanol / 2062.71 Torr

3: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 100 °C / Inert atmosphere

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 1 h / 60 °C / Inert atmosphere

5: ethanol / 7 h / 154 °C / Microwave irradiation

6: pyridine / 2 h / 20 °C / Cooling with ice

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; hydrogen; nitric acid; potassium acetate; potassium carbonate; In 1,4-dioxane; ethanol; water; 6: |Schotten-Baumann Reaction;
DOI:10.1021/acs.jmedchem.5b00067

Reference yield:

: 1455035-96-7
7-chloro-2-methyl[1,6]naphthyridin-3-yl trifluoromethanesulfonate

: 1455036-94-8
prop-1-en-2-yl (2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)[1,6]naphthyridin-3-yl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 1 h / 60 °C / Inert atmosphere

2: ethanol / 7 h / 154 °C / Microwave irradiation

3: pyridine / 2 h / 20 °C / Cooling with ice

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; 3: |Schotten-Baumann Reaction;
DOI:10.1021/acs.jmedchem.5b00067