N-(5-Hydroxypyridin-2-yl)acetamide

Base Information

• Chemical Name: N-(5-Hydroxypyridin-2-yl)acetamide
• CAS No.: 159183-89-8
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.153
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID80598571
• Nikkaji Number: J2.809.820K
• Wikidata: Q82494345
• Mol file: 159183-89-8.mol

Synonyms:N-(5-Hydroxypyridin-2-yl)acetamide;159183-89-8;N-(5-HYDROXY-PYRIDIN-2-YL)-ACETAMIDE;2-acetylamino-5-hydroxypyridine;2-Acetamido-5-hydroxypyridine;SCHEMBL1977386;DTXSID80598571;NOHYOJBXOLFMHD-UHFFFAOYSA-N;MFCD09839685;AKOS006329197;DS-6384;SB33973;DB-064268;CS-0153958;C73008;A883321

Chemical Property of N-(5-Hydroxypyridin-2-yl)acetamide

Chemical Property:

• PSA: 65.71000
• LogP: 1.39510
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 152.058577502
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

97% ^*data from raw suppliers

N-(5-Hydroxypyridin-2-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=NC=C(C=C1)O

Technology Process of N-(5-Hydroxypyridin-2-yl)acetamide

There total 5 articles about N-(5-Hydroxypyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-acetamido-5-benzyloxypyridine (1204413-49-9) → 2-acetamido-5-hydroxypyridine (159183-89-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 760.051 Torr;

DOI:10.1039/b912528k

Reference yield: 30.0%

2-amino-5-hydroxypyridine hydrochloride (856965-37-2) + acetyl chloride (75-36-5) → 2-acetamido-5-hydroxypyridine (159183-89-8)

Guidance literature:

2-amino-5-hydroxypyridine hydrochloride; acetyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 3h;

With sodium hydroxide; In water; at 20 ℃; for 0.5h;

DOI:10.1016/j.bioorg.2020.104130

Reference yield:

N-(5-methoxy-2-pyridyl)acetamide (76066-09-6) → 2-acetamido-5-hydroxypyridine (159183-89-8)

Guidance literature:

In methanol; dichloromethane; dimethyl sulfoxide;

upstream raw materials:

N-(5-methoxy-2-pyridyl)acetamide

2-acetamido-5-benzyloxypyridine

2-amino-5-hydroxypyridine hydrochloride

acetyl chloride

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