benzyl 3-{2-[5-(((benzyloxycarbonylamino)-(benzyloxycarbonylimino)methyl)amino)pentylcarbonylamino]-1,3-thiazol-4-ylmethylcarbonylamino}-3-butylcarbamoylpropanoate

Base Information

Chemical Name:benzyl 3-{2-[5-(((benzyloxycarbonylamino)-(benzyloxycarbonylimino)methyl)amino)pentylcarbonylamino]-1,3-thiazol-4-ylmethylcarbonylamino}-3-butylcarbamoylpropanoate
CAS No.:945469-85-2
Molecular Formula:C₄₃H₅₁N₇O₉S
Molecular Weight:841.985
Hs Code.:

benzyl 3-{2-[5-(((benzyloxycarbonylamino)-(benzyloxycarbonylimino)methyl)amino)pentylcarbonylamino]-1,3-thiazol-4-ylmethylcarbonylamino}-3-butylcarbamoylpropanoate

Synonyms:benzyl 3-{2-[5-(((benzyloxycarbonylamino)-(benzyloxycarbonylimino)methyl)amino)pentylcarbonylamino]-1,3-thiazol-4-ylmethylcarbonylamino}-3-butylcarbamoylpropanoate

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Chemical Property of benzyl 3-{2-[5-(((benzyloxycarbonylamino)-(benzyloxycarbonylimino)methyl)amino)pentylcarbonylamino]-1,3-thiazol-4-ylmethylcarbonylamino}-3-butylcarbamoylpropanoate

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Technology Process of benzyl 3-{2-[5-(((benzyloxycarbonylamino)-(benzyloxycarbonylimino)methyl)amino)pentylcarbonylamino]-1,3-thiazol-4-ylmethylcarbonylamino}-3-butylcarbamoylpropanoate

There total 10 articles about benzyl 3-{2-[5-(((benzyloxycarbonylamino)-(benzyloxycarbonylimino)methyl)amino)pentylcarbonylamino]-1,3-thiazol-4-ylmethylcarbonylamino}-3-butylcarbamoylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 945469-85-2
benzyl 3-{2-[5-(((benzyloxycarbonylamino)-(benzyloxycarbonylimino)methyl)amino)pentylcarbonylamino]-1,3-thiazol-4-ylmethylcarbonylamino}-3-butylcarbamoylpropanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 87.5 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / ethyl acetate / cooling

2.1: 84.7 percent / NaOH / methanol; H₂O / 1 h / 20 °C

3.1: triethylamine; 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / CH₂Cl₂

3.2: 84 percent / methanol / CH₂Cl₂ / 0.08 h / 20 °C

4.1: N-methylmorpholine / dimethylformamide / -30 °C

5.1: 1.15 g / dimethylformamide / cooling

6.1: formic acid; anisole / 3 h / 20 °C

7.1: triethylamine / CH₂Cl₂; acetonitrile / 12 h / Heating

With 4-methyl-morpholine; sodium hydroxide; formic acid; benzotriazol-1-ol; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/00908320701230117

Reference yield:

: 878010-67-4
2-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl]acetic acid

: 945469-85-2
benzyl 3-{2-[5-(((benzyloxycarbonylamino)-(benzyloxycarbonylimino)methyl)amino)pentylcarbonylamino]-1,3-thiazol-4-ylmethylcarbonylamino}-3-butylcarbamoylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / CH₂Cl₂

1.2: 84 percent / methanol / CH₂Cl₂ / 0.08 h / 20 °C

2.1: N-methylmorpholine / dimethylformamide / -30 °C

3.1: 1.15 g / dimethylformamide / cooling

4.1: formic acid; anisole / 3 h / 20 °C

5.1: triethylamine / CH₂Cl₂; acetonitrile / 12 h / Heating

With 4-methyl-morpholine; formic acid; benzotriazol-1-ol; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/00908320701230117

Reference yield:

: 878010-66-3
ethyl 2-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl]acetate

: 945469-85-2
benzyl 3-{2-[5-(((benzyloxycarbonylamino)-(benzyloxycarbonylimino)methyl)amino)pentylcarbonylamino]-1,3-thiazol-4-ylmethylcarbonylamino}-3-butylcarbamoylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 84.7 percent / NaOH / methanol; H₂O / 1 h / 20 °C

2.1: triethylamine; 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / CH₂Cl₂

2.2: 84 percent / methanol / CH₂Cl₂ / 0.08 h / 20 °C

3.1: N-methylmorpholine / dimethylformamide / -30 °C

4.1: 1.15 g / dimethylformamide / cooling

5.1: formic acid; anisole / 3 h / 20 °C

6.1: triethylamine / CH₂Cl₂; acetonitrile / 12 h / Heating

With 4-methyl-morpholine; sodium hydroxide; formic acid; benzotriazol-1-ol; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/00908320701230117