benzyl 3-carboxy-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl-methylcarbonylamino]propanoate

Base Information

Chemical Name:benzyl 3-carboxy-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl-methylcarbonylamino]propanoate
CAS No.:945469-83-0
Molecular Formula:C₂₇H₃₆N₄O₈S
Molecular Weight:576.671
Hs Code.:

Synonyms:benzyl 3-carboxy-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl-methylcarbonylamino]propanoate

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Chemical Property of benzyl 3-carboxy-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl-methylcarbonylamino]propanoate

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Technology Process of benzyl 3-carboxy-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl-methylcarbonylamino]propanoate

There total 5 articles about benzyl 3-carboxy-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl-methylcarbonylamino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 878010-67-4
2-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl]acetic acid

: C₁₄H₂₁NO₄Si*HCl

: 945469-83-0
benzyl 3-carboxy-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl-methylcarbonylamino]propanoate

Guidance literature:: 2-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl]acetic acid; C₁₄H₂₁NO₄Si*HCl; With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

With methanol; In dichloromethane; at 20 ℃; for 0.0833333h; Further stages.;
DOI:10.1080/00908320701230117

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 945469-83-0
benzyl 3-carboxy-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl-methylcarbonylamino]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 87.5 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / ethyl acetate / cooling

2.1: 84.7 percent / NaOH / methanol; H₂O / 1 h / 20 °C

3.1: triethylamine; 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / CH₂Cl₂

3.2: 84 percent / methanol / CH₂Cl₂ / 0.08 h / 20 °C

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; ethyl acetate;
DOI:10.1080/00908320701230117

Reference yield:

: 878010-66-3
ethyl 2-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl]acetate

: 945469-83-0
benzyl 3-carboxy-3-[2-(5-(tert-butyloxycarbonylamino)pentylcarbonylamino)-1,3-thiazol-4-yl-methylcarbonylamino]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 84.7 percent / NaOH / methanol; H₂O / 1 h / 20 °C

2.1: triethylamine; 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / CH₂Cl₂

2.2: 84 percent / methanol / CH₂Cl₂ / 0.08 h / 20 °C

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water;
DOI:10.1080/00908320701230117