2-chloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}acetamide

Base Information

Chemical Name:2-chloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}acetamide
CAS No.:1429878-99-8
Molecular Formula:C₃₁H₃₀Cl₂N₂O₂
Molecular Weight:533.497
Hs Code.:

Synonyms:2-chloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}acetamide

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Chemical Property of 2-chloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}acetamide

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Technology Process of 2-chloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}acetamide

There total 4 articles about 2-chloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1429878-98-7
2-[2-(3-amino-3-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}propyl)phenyl]propan-2-ol

: 79-04-9
chloroacetyl chloride

: 1429878-99-8
2-chloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}acetamide

Guidance literature:: With triethylamine; In dichloromethane;

Reference yield:

: 1079753-36-8
C₂₉H₂₈ClNO₂

: 1429878-99-8
2-chloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / toluene; acetonitrile / 3 h / -25 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 12 h / 20 °C

3: triphenylphosphine; water / tetrahydrofuran / 36 h / 20 °C

4: triethylamine / dichloromethane

With sodium azide; water; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1429878-96-5
C₃₀H₃₀ClNO₄S

: 1429878-99-8
2-chloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 12 h / 20 °C

2: triphenylphosphine; water / tetrahydrofuran / 36 h / 20 °C

3: triethylamine / dichloromethane

With sodium azide; water; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;