2-[2-(2-methoxy-4-morpholin-4-yl-phenylamino)-5-vinyl-pyridin-4-ylamino]-N-methyl-benzamide

Base Information

Chemical Name:2-[2-(2-methoxy-4-morpholin-4-yl-phenylamino)-5-vinyl-pyridin-4-ylamino]-N-methyl-benzamide
CAS No.:1184931-47-2
Molecular Formula:C₂₆H₂₉N₅O₃
Molecular Weight:459.548
Hs Code.:

Synonyms:2-[2-(2-methoxy-4-morpholin-4-yl-phenylamino)-5-vinyl-pyridin-4-ylamino]-N-methyl-benzamide

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Chemical Property of 2-[2-(2-methoxy-4-morpholin-4-yl-phenylamino)-5-vinyl-pyridin-4-ylamino]-N-methyl-benzamide

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Technology Process of 2-[2-(2-methoxy-4-morpholin-4-yl-phenylamino)-5-vinyl-pyridin-4-ylamino]-N-methyl-benzamide

There total 4 articles about 2-[2-(2-methoxy-4-morpholin-4-yl-phenylamino)-5-vinyl-pyridin-4-ylamino]-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 209960-91-8
2-methoxy-4-morpholinoaniline

: 1184931-60-9
2-(2-chloro-5-vinyl-pyridin-4-ylamino)-N-methyl-benzamide

: 1184931-47-2
2-[2-(2-methoxy-4-morpholin-4-yl-phenylamino)-5-vinyl-pyridin-4-ylamino]-N-methyl-benzamide

Guidance literature:: With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 50 - 100 ℃; Inert atmosphere; sealed tube;

Reference yield:

: 4141-08-6
2-Amino-N-methylbenzamid

: 1184931-47-2
2-[2-(2-methoxy-4-morpholin-4-yl-phenylamino)-5-vinyl-pyridin-4-ylamino]-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water; isopropyl alcohol / 96 h / 95 °C / vessel sealed

2: potassium phosphate / water; toluene / 50 °C / Reflux; Inert atmosphere

3: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 50 - 100 °C / Inert atmosphere; sealed tube

With hydrogenchloride; potassium phosphate; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; water; isopropyl alcohol; toluene;

Reference yield:

: 1184931-54-1
2-[(5-bromo-2-chloro-4-pyridinyl)amino]-N-methylbenzamide

: 1184931-47-2
2-[2-(2-methoxy-4-morpholin-4-yl-phenylamino)-5-vinyl-pyridin-4-ylamino]-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / water; toluene / 50 °C / Reflux; Inert atmosphere

2: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 50 - 100 °C / Inert atmosphere; sealed tube

With potassium phosphate; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; water; toluene;