N-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)-L-leucine

Base Information

Chemical Name:N-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)-L-leucine
CAS No.:1351814-93-1
Molecular Formula:C₂₁H₃₂N₂O₅
Molecular Weight:392.495
Hs Code.:

Synonyms:N-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)-L-leucine

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Chemical Property of N-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)-L-leucine

Chemical Property:

Purity/Quality:

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Technology Process of N-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)-L-leucine

There total 8 articles about N-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912545-08-5
2,4-bis-benzyloxy-5-isopropenyl-benzoic acid methyl ester

: 1351814-93-1
N-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)-L-leucine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; methanol / 20 h / 75 °C

1.2: 0.5 h / 20 °C

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 18 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h

4.1: sodium hydroxide; methanol / 20 °C

With methanol; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; sodium hydroxide; dmap; palladium 10% on activated carbon; In dichloromethane; ethyl acetate;

Reference yield:

: 1351813-99-4
cyclopentyl N-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)-L-leucinate

: 1351814-93-1
N-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)-L-leucine

Guidance literature:: cyclopentyl N-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)-L-leucinate; With methanol; sodium hydroxide; at 20 ℃;

With hydrogenchloride; In methanol; water; Product distribution / selectivity;

Reference yield:

: 2150-47-2
methyl 2,4-dihydroxybenzoate

: 1351814-93-1
N-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)-L-leucine

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap / 1 h / 55 °C

2.1: trifluorormethanesulfonic acid / toluene / 2.5 h / 20 °C / Cooling with ice

2.2: 18 h / 20 °C

3.1: potassium carbonate / acetonitrile / 42 h / 75 °C

4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

4.2: 0.5 h

5.1: potassium hydroxide; methanol / 20 h / 75 °C

5.2: 0.5 h / 20 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 18 h / 20 °C

7.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h

8.1: sodium hydroxide; methanol / 20 °C

With methanol; trifluorormethanesulfonic acid; potassium tert-butylate; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; sodium hydroxide; dmap; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene; acetonitrile;