2-(4-(6-fluoropyridin-2-yl)benzyl)-7-(4-methoxybenzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Base Information

Chemical Name:2-(4-(6-fluoropyridin-2-yl)benzyl)-7-(4-methoxybenzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
CAS No.:1520918-63-1
Molecular Formula:C₂₆H₂₂FN₅O₃
Molecular Weight:471.491
Hs Code.:

Synonyms:2-(4-(6-fluoropyridin-2-yl)benzyl)-7-(4-methoxybenzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Suppliers and Price of 2-(4-(6-fluoropyridin-2-yl)benzyl)-7-(4-methoxybenzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-(6-fluoropyridin-2-yl)benzyl)-7-(4-methoxybenzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Chemical Property:

Purity/Quality:: 99% ,98%,Electron Grade , ^*data from raw suppliers

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Technology Process of 2-(4-(6-fluoropyridin-2-yl)benzyl)-7-(4-methoxybenzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

There total 5 articles about 2-(4-(6-fluoropyridin-2-yl)benzyl)-7-(4-methoxybenzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(4-(chloromethyl)phenyl)-6-fluoropyridine: 1228684-04-5
2-(4-(chloromethyl)phenyl)-6-fluoropyridine

: 1351961-59-5,916764-91-5
7-(4-methoxybenzyl)-5-methyl-2,7-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4,6(5H)-dione

: 1520918-63-1
2-(4-(6-fluoropyridin-2-yl)benzyl)-7-(4-methoxybenzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl acetamide; at 45 ℃; for 5h;

Reference yield: 97.0%

: 1351961-59-5,916764-91-5
7-(4-methoxybenzyl)-5-methyl-2,7-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4,6(5H)-dione

: 2-(4-(bromomethyl)phenyl)-6-fluoropyridine

: 1520918-63-1
2-(4-(6-fluoropyridin-2-yl)benzyl)-7-(4-methoxybenzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b01751

Reference yield:

: 144100-07-2
2-bromo-6-fluoropyridine

: 1520918-63-1
2-(4-(6-fluoropyridin-2-yl)benzyl)-7-(4-methoxybenzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 4 h / 65 °C / Inert atmosphere

2: thionyl chloride; N,N-dimethyl-formamide / ethyl acetate / 1 h / 20 °C

3: potassium carbonate / N,N-dimethyl acetamide / 5 h / 45 °C

With bis-triphenylphosphine-palladium(II) chloride; thionyl chloride; sodium carbonate; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl acetamide; water; ethyl acetate;