PDE4 (R)-(-)-RolipraM

Base Information

Chemical Name:PDE4 (R)-(-)-RolipraM
CAS No.:1160521-50-5
Molecular Formula:C29H26FN7O
Molecular Weight:507.57
Hs Code.:
Mol file:1160521-50-5.mol

Synonyms:PDE4 (R)-(-)-RolipraM;PDE1-IN-1;ITI214 (free base)

Suppliers and Price of PDE4 (R)-(-)-RolipraM

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
ITI214freebase 98+%
10mg
$ 347.00

Crysdot
ITI214freebase 98+%
5mg
$ 243.00

Crysdot
ITI214freebase 98+%
50mg
$ 1042.00

ChemScene
ITI-214(freebase) >98.0%
50mg
$ 950.00

ChemScene
ITI-214(freebase) >98.0%
10mg
$ 350.00

ChemScene
ITI-214(freebase) >98.0%
5mg
$ 190.00

Total 5 raw suppliers

Chemical Property of PDE4 (R)-(-)-RolipraM

Chemical Property:

Boiling Point:731.7±70.0 °C(Predicted)
PKA:2.06±0.20(Predicted)
PSA：82.03000
Density:1.45±0.1 g/cm3(Predicted)
LogP:4.04600

Purity/Quality:

97% ^*data from raw suppliers

ITI214freebase 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of PDE4 (R)-(-)-RolipraM

There total 10 articles about PDE4 (R)-(-)-RolipraM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351960-86-5
2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

: 1160521-50-5
(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / tetrahydrofuran / 1 h / 20 °C

1.2: 5 h / 20 °C

2.1: dmap; p-toluenesulfonyl chloride; triethylamine / tetrahydrofuran / 10 h / 50 °C

2.2: 2 h / 20 °C

3.1: N-chloro-succinimide; lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.5 h / 0 °C / Inert atmosphere

4.1: potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / Inert atmosphere

With dmap; N-chloro-succinimide; palladium diacetate; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; p-toluenesulfonyl chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl acetamide; toluene;

Reference yield:

: 1520918-65-3
2-(4-(6-fluoropyridin-2-yl)benzyl)-6-(((1R,2R)-2-hydroxycyclopentyl)amino)-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

: 1160521-50-5
(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; p-toluenesulfonyl chloride; triethylamine / tetrahydrofuran / 10 h / 50 °C

1.2: 2 h / 20 °C

2.1: N-chloro-succinimide; lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.5 h / 0 °C / Inert atmosphere

3.1: potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / Inert atmosphere

With dmap; N-chloro-succinimide; palladium diacetate; potassium carbonate; triethylamine; p-toluenesulfonyl chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl acetamide; toluene;

Reference yield:

: 1228658-88-5
(6aR,9aS)-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one

: 1160521-50-5
(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-chloro-succinimide; lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.5 h / 0 °C / Inert atmosphere

2: potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / Inert atmosphere

With N-chloro-succinimide; palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl acetamide; toluene;