Technology Process of 2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide
There total 8 articles about 2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diethyl dicarbonate;
In
tetrahydrofuran;
at 0 - 80 ℃;
- Guidance literature:
-
With
diethyl cyanophosphonate;
In
tetrahydrofuran;
at 0 - 80 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 100 °C
1.2: 3 h / 100 °C
2.1: toluene-4-sulfonic acid / acetic acid / 3 h / Reflux
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 0 - 80 °C / 3102.97 Torr
4.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide; ethanol / 2 h / Reflux
5.1: diethyl dicarbonate / tetrahydrofuran / 0 - 80 °C
With
hydrogen; sodium hydride; toluene-4-sulfonic acid; diethyl dicarbonate;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; acetic acid; N,N-dimethyl-formamide; mineral oil;