2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide

Base Information

Chemical Name:2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide
CAS No.:1338064-97-3
Molecular Formula:C₁₇H₁₃F₃N₂O₃
Molecular Weight:350.297
Hs Code.:

Synonyms:2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide

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Chemical Property of 2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide

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Technology Process of 2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide

There total 8 articles about 2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

: 54523-76-1
4-aminoindolin-2-one

: 32857-62-8
4-Trifluoromethylphenylacetic acid

: 1338064-97-3
2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide

Guidance literature:: With diethyl dicarbonate; In tetrahydrofuran; at 0 - 80 ℃;

Reference yield: 78.5%

: 148890-63-5
5-amino-4H-benz[1,4]oxazin-3-one

: 32857-62-8
4-Trifluoromethylphenylacetic acid

: 1338064-97-3
2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide

Guidance literature:: With diethyl cyanophosphonate; In tetrahydrofuran; at 0 - 80 ℃;

Reference yield:

: 606-21-3
1-chloro-2,6-dinitrobenzene

: 1338064-97-3
2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 100 °C

1.2: 3 h / 100 °C

2.1: toluene-4-sulfonic acid / acetic acid / 3 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 0 - 80 °C / 3102.97 Torr

4.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide; ethanol / 2 h / Reflux

5.1: diethyl dicarbonate / tetrahydrofuran / 0 - 80 °C

With hydrogen; sodium hydride; toluene-4-sulfonic acid; diethyl dicarbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; acetic acid; N,N-dimethyl-formamide; mineral oil;