148890-63-5

Basic information

• Product Name: 5-AMINO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE
• Synonyms: 5-Amino-3,4-dihydro-2H-1,4-benzoxazin-3-one;2H-1,4-Benzoxazin-3(4H)-one, 5-amino-;5-Amino-2H-benzo[b][1,4]oxazin-3(4H);5-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE;5-AMINO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE;OTAVA-BB 1329496;3,4-Dihydro-3-oxo-2H-1,4-benzoxazin-5-amine;5-Amino-4H-benzo[1,4]oxazin-3-one
• CAS NO: 148890-63-5
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164.163
• Mol File: 148890-63-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-AMINO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE(148890-63-5)
• EPA Substance Registry System: 5-AMINO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE(148890-63-5)

Safety Data

• Hazardous Substances Data: 148890-63-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-AMINO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE is used as a building block for the development of novel compounds with potential biological activities. Its unique structure and properties make it a promising candidate for the creation of new pharmaceuticals with therapeutic applications.
Used in Materials Science:
In the field of materials science, 5-AMINO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE is utilized as a component in the synthesis of advanced materials with specific properties. Its chemical structure allows for the development of materials with potential applications in various industries, such as electronics, coatings, and adhesives.
Used in Organic Synthesis:
5-AMINO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE serves as a key intermediate in organic synthesis, enabling the production of a wide range of chemical compounds. Its reactivity and functional groups make it a valuable precursor for the synthesis of various organic molecules with diverse applications.
Further research and exploration of the properties of 5-AMINO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE are essential to fully understand its potential uses and applications across different industries. As a versatile building block, it holds promise for the development of innovative products and technologies.

Upstream product

• 603-85-0 2-Amino-3-nitrophenol 
• 132522-81-7 3,4-dihydro-5-nitro-2H-1,4-benzoxazin-3-one 

Downstream Products

• 1338064-82-6 1-(4-(trifluoromethyl)-2-(piperidin-1-yl)benzyl)-3-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)urea 
• 1338064-81-5 1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)urea 
• 1338064-80-4 1-(4-(trifluoromethyl)benzyl)-3-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)urea 
• 1338064-97-3 2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide 
• 888038-47-9 1-(3,4,5-trifluoro-phenyl)-piperidine-4-carboxylic acid (3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-5-yl)-amide 

Relevant articles and documents

"TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION"

The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active

TRPV1 vanilloid receptor antagonists with a bicyclic portion

The invention discloses compounds of formula I wherein Y s selected from a group of formula and W, Q, n, R1, R2, R3, U1-U5 have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of the vanilloid receptor TRPV1. 1.

ALKYL-SUBSTITUTED 3' COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, Ar, m and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

CONDENSED HETEROCYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I) wherein R1, A, B, D, E, G, Q, Ar, n, m, and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

ACYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, R5, Q, G, Ar, m, and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): formula (I) wherein Cy is selected from formula (Il) and wherein R1, R2, R3, Q, G, Ar, m, n and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

PYRROLIDINE-SUBSTITUTED AZAINDOLE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, A, B, D, E, G, Ar, and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

3' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein Q, R1, R4, m and Ar are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

4' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, R5, R6, B, D, E, G, Q, x and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

6' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1—R4 A, B, D, E, and G are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.