(R)-N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

Base Information

Chemical Name:(R)-N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide
CAS No.:926036-50-2
Molecular Formula:C₂₀H₂₀F₄IN₃O
Molecular Weight:521.296
Hs Code.:

Synonyms:(R)-N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

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Chemical Property of (R)-N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

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Technology Process of (R)-N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

There total 5 articles about (R)-N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: dimethyl-[1-(2-nitro-4-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-amine

: 926036-50-2
(R)-N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 20 °C

2: iPr₂NEt / CH₂Cl₂ / 3 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm061112p

Reference yield:

: 367-86-2
1-fluoro-2-nitro-4-trifluoromethyl-benzene

: 926036-50-2
(R)-N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium bicarbonate / tetrahydrofuran / 14 h / 70 °C

2: H₂ / Pd/C / methanol / 20 °C

3: iPr₂NEt / CH₂Cl₂ / 3 h / 20 °C

With hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm061112p

Reference yield:

: (R)-(+)-3-(dimethylamino)pyrrolidine

: 926036-50-2
(R)-N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium bicarbonate / tetrahydrofuran / 14 h / 70 °C

2: H₂ / Pd/C / methanol / 20 °C

3: iPr₂NEt / CH₂Cl₂ / 3 h / 20 °C

With hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm061112p